background: evaluation of anti-mullerian hormone (amh) cut-off levels in assisted reproductive technology (art) as predictive factor for individualization of stimulation protocols and to avoid ovarian hyperstimulation syndrome (ohss). materials and methods: in a retrospective study, 177 infertile patients were assessed for amh in serum and follicular fluid (ff) on the day of follicular puncture...

background: one of the major and life-threatening side effects of assisted reproductive technique (art) is ovarian hyperstimulation syndrome (ohss). the available data however, have been showed that both cabergoline (anti vegf) and coasting reduce the severity of ohss. objective: we aimed to compare coasting and cabergoline administration in prevention of severe ohss. materials and methods: a t...

BACKGROUND Evaluation of anti-mullerian hormone (AMH) cut-off levels in as- sisted reproductive technology (ART) as predictive factor for individualization of stimulation protocols and to avoid ovarian hyperstimulation syndrome (OHSS). MATERIALS AND METHODS In a retrospective study, 177 infertile patients were as- sessed for AMH in serum and follicular fluid (FF) on the day of follicular punc...

CONTEXT Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of treatment with fertility drugs. It is characterized by increased vascular permeability and simultaneous overexpression of vascular endothelial growth factor (VEGF) in ovarian cells. OBJECTIVE We tested the hypothesis that the endothelium and endothelial cell-to-cell junctions are downstream targets of VEGF durin...

Ovarian hyperstimulation syndrome (OHSS) can be a severe and potentially life-threatening complication of ovarian stimulation for IVF. Coasting or withholding gonadotrophin stimulation relies on frequent estimation of serum oestradiol to identify patients at risk. A modified coasting protocol was developed in which identification of patients at risk of severe OHSS was based on ultrasound monito...

BACKGROUND The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH). METHODS This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a regi...

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is considered to be an iatrogenic complication of ovulation induction therapy. However, OHSS may rarely be associated with spontaneous ovulatory cycles, usually in multiple or molar gestations or hypothyroidism. Clinical manifestations vary and may be potentially fatal in severe cases. CASE REPORT A 28-year-old primigravid, with no history o...

Ovarian stimulation of the high responder remains controversial. The narrow margin between a too low gonadotrophin dose (and abnormal oestradiol rise) and excessive stimulation (risk of OHSS) is a challenging situation. This study describes an OHSS-free protocol, based on the use of recombinant gonadotrophins for stimulation and gonadotrophin-releasing hormone (GnRH) antagonist to prevent prema...

BACKGROUND Triggering ovulation by GnRH agonist (GnRHa) in GnRH antagonist IVF protocols coupled with adequate luteal phase support has recently been suggested as a means to prevent ovarian hyperstimulation syndrome (OHSS). Our objective was to examine the outcome of fresh embryo transfer (f-ET) after triggering ovulation by GnRHa and providing intensive luteal phase supplementation, compared w...

BACKGROUND The aim of this study is to report a large series of patients (n = 1223) at risk of developing ovarian hyperstimulation syndrome (OHSS) who underwent coasting. METHODS Coasting started when the leading follicle reached 16 mm and continued until the estradiol (E2) level fell to 3000 pg/ml. RESULTS The E2 level at the start of coasting was (mean +/ SD) 6408 +/- 446 and it fell to 2...