The H+,K+-ATPase has been postulated to be the enzyme responsible for H+ secretion by the parietal cell. Omeprazole has been shown to be an inhibitor of acid secretion in vivo, but also in in vitro test models for acid secretion, including partly purified H+,K+-ATPase, the inhibitory action of omeprazole has been demonstrated (Wallmark, B., Jaresten, B. M., Larsson, H., Ryberg, B., Brändström, ...

The effects of omeprazole--an inhibitor of gastric acid secretion--on gastrin (G)- and somatostatin (D)-cell density in the gastric antral mucosa epithelium in rats were examined, following a 5-day treatment. It was found that omeprazole increased the density of G-cells, whereas it decreased the density of D-cells. That effect was probably independent of hypergastrinaemia, since it could not be...

BACKGROUND Several epidemiologic studies have suggested the association between therapy with proton pump inhibitors (PPIs) and bone fractures. AIM This study aimed at evaluating the effect of omeprazole on bone in normal and ovariectomized Wistar rats and the possible mechanisms involved. MATERIALS AND METHODS 56 rats were divided into 3 main groups. Normal group; further subdivided into no...

aim :  the goal of the present study was to assess the effect of omeprazole on bone mineral density and frequency of osteopenia and osteoporosis. background : the effect of omeprazole on bone turnover and the role of stomach ph alteration in calcium absorption have not been completely understood. patients and methods : in a case-control study, 58 patients who were referred to loghman hospital, ...

about 1.5-6 % of the patients with gastric and duodenal erosions admitted to i.c.u. are prone to gastrointestinal (g.i.) bleeding with its ensuing complications. routine prophylaxis with h2-blockers and anti-acid has been used in these high risk patients for decades. in this study we evaluated the effect of p.o omeprazole, a potent acid inhibitor with prolong effects on gastric ph.  patients wi...

This study was designed to investigate whether proton pump inhibitors (PPI, V-ATPase blocker) could increase the effect of cytotoxic agents in chemoresistant epithelial ovarian cancer (EOC). Expression of V-ATPase protein was evaluated in patients with EOC using immunohistochemistry, and patient survival was compared based on expression of V-ATPase mRNA from a TCGA data set. In vitro, EOC cell ...

PURPOSE Gastroesophageal reflux disease (GERD) occurs in pediatric patients when reflux of gastric contents presents with troublesome symptoms. The present study compared the effects of omeprazole and ranitidine for the treatment of symptomatic GERD in infants of 2-12 months. METHODS This study was a clinical randomized double-blind trial and parallel-group comparison of omeprazole and raniti...

The adsorption of the proton-pump inhibitor omeprazole was investigated using RP-LC with chemometric models combined with adsorption isotherm modelling to study the effect of pH and type of organic modifier (i.e., acetonitrile or methanol). The chemometric approach revealed that omeprazole was tailing with methanol and fronting with acetonitrile along with increased fronting at higher pH. The i...

BACKGROUND Many patients with coronary artery disease (CAD) have overlapping gastroenterological causes of recurrent chest pain, mainly due to gastroesophageal reflux (GER) and aspirin-induced gastrointestinal tract damage. These symptoms can be alleviated by proton pump inhibitors (PPIs). The study addressed whether omeprazole treatment also affects general health-related quality of life (HRQL...