Conceptual Integrity has been claimed to be the essence of high-quality software system design. On the other hand, it has been a rather elusive attribute of software systems, challenging various attempts of a clear-cut characterization. This paper evolves in this direction by two means: first, by analysis and clarification of open issues in architecture and abstraction terms; second, by pointin...

Building software systems is hard; evolving them is harder. Even with complete requirements, architecture and design documentation, comprehending a system, or even a part of a system, in such a way as to understand the implications of the changes we make is a difficult task. I believe that the separation of architecture from design helps us with the problem of system comprehension: identifying ...

Since 2007, September has been Colorectal Cancer Awareness Month, which has been sponsored by the Korean Society of Coloproctology (KSCP) to raise awareness of colorectal neoplasms [1]. A significant increase was seen in the percentage of informationsharing tweets from 77.1% to 81.1% (P = 0.045) during the 2014 Colorectal Cancer Awareness Month. In addition, most of the Korean tweets seen durin...

BACKGROUND AND OBJECTIVE To compare ranibizumab (Lucentis; Genentech, South San Francisco, CA) 0.5 mg and 1.0 mg for the treatment of clinically significant diabetic macular edema (CSDME). PATIENTS AND METHODS This was a 12-month, prospective, single-masked, randomized clinical trial. Patients with CSDME secondary to diabetic retinopathy were randomized to receive 0.5 mg or 1.0 mg of ranibizu...

An open label, multi-center, 6 months observational study of new fixed combination (travoprost 0.004%/timolol 0.5%), in order to evaluate both efficacy (intraocular pressure lowering) and tolerability (patient and investigator satisfaction) of two dosing regimens--evening (PM) and morning (AM). After screening for enrollment, to 40 patients (79 eyes with primary open angle glaucoma or ocular hy...