The autosomal dominant form of Alzheimer's disease (ADAD) is far less prevalent than late onset Alzheimer's disease (LOAD), but enables well-informed prospective studies, since symptom onset is near certain and age of onset is predictable. Our aim was to discover plasma proteins associated with early AD pathology by investigating plasma protein changes at the asymptomatic and symptomatic stages...

Atomistic mechanisms of nanoindentation of a-SiC have been studied by molecular dynamics simulations. The load displacement curve exhibits a series of load drops, reflecting the short-range topological order similar to crystalline 3C–SiC. In contrast to 3C–SiC, the load drops are irregularly spaced and less pronounced. The damage is spatially more extended than in 3C–SiC, and it exhibits long-r...

BACKGROUND The flexion relaxation phenomenon (FRP) represents a well-studied neuromuscular response that occurs in the lumbar and cervical spine. However, the cervical spine FRP has not been investigated extensively, and the speed of movement and loading effects remains to be characterized. The objectives of the present study were to evaluate the influence of load and speed on cervical FRP elec...

in the current engineering practices, buildings are commonly designed for an effective lifetime of 50 years. this lifetime can increase the cost of buildings with short lifetimes and can reduce the safety level of buildings with large lifetimes. in this paper, a “service-life factor” has been defined. applying this factor into the nominal values of live, earthquake, wind, and snow loads, the ef...

Background: Sport is an activity that has a positive effect on individual. DOMS occurs when person starts exercising after long period of inactivity and results from increase in the load intensity exercise. characterized by onset muscle soreness Any type places unusual muscles can cause DOMS.Objective: to determine existence active recovery passive reducing (delayed soreness).Method: The study ...

This paper presents the application of interval type-2 fuzzy inference systems (IT2FIS) in short term load forecasting (STLF) on special days. This is a continuation work of application interval type-2 fuzzy systems (IT2FSs) using Karnik Mendel algorithm. Special days here mean local Balinese holidays such as national and local culture-based public holidays, consecutive holidays, and days prece...

framed in a cognitive approach to task-supported l2 vocabulary learning, the present study used a pedagogical approach to investigate the relative effectiveness of tasks with different involvement loads on the vocabulary knowledge of iranian efl learners. the goal was to investigate the way that the construct of involvement load is related to the input hypothesis (krashen, 1985) and the output ...

Background: The early cellular stresses leading to Alzheimer’s disease (AD) remain poorly understood because we cannot access living, asymptomatic human AD brains for detailed molecular analyses. Sortilin-related receptor 1 (SORL1) encodes a multi-domain protein genetically associated with both rare, early-onset familial (EOfAD) and common, sporadic, late-onset (LOAD). SORL1 has been shown act ...

BACKGROUND The default mode network (DMN) is a set of brain regions typically activated at rest and suppressed during extrinsic cognition. Schizophrenia has been associated with deficient DMN suppression, though the extent to which DMN dysfunction predates psychosis onset is unclear. This study examined DMN suppression during working memory (WM) performance in youth at clinical high-risk (CHR) ...