Introduction: Pseudomonas aeruginosa is an ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, P. aeruginosa, and Enterobacter spp.) pathogen one of the leading etiologies in multiple nosocomial infections. Treatment becoming increasingly difficult due to its ever-increasing antibiotic resistance trends. This study investigated clinical multidrug...

Biogenic polyamines (e.g., spermidine and spermine) are a group of essential polycationic compounds found in all living cells. The effects of spermine and spermidine on antibiotic susceptibility were examined with gram-negative Escherichia coli and Salmonella enterica serovar Typhimurium bacteria and clinical isolates of Pseudomonas aeruginosa and with gram-positive Staphylococcus aureus bacter...

To study the epidemiology of Pseudomonas aeruginosa colonization in a 32-bed burn wound center (BWC), 321 clinical and 45 environmental P. aeruginosa isolates were collected by prospective surveillance culture over a 1-year period and analyzed by serotyping, drug susceptibility testing, and amplified fragment length polymorphism (AFLP) analysis. Among 441 patients treated at the center, 70 (16%...

Ceftolozane plus tazobactam is an antipseudomonal cephalosporin combined with tazobactam, an established beta-lactamase inhibitor, and has in vitro potency against a range of clinically important β-lactamase-producing bacteria, including most extended-spectrum-β-lactamase (ESBL)-positive Enterobacteriaceae. The pharmacodynamics of β-lactam-β-lactamase inhibitor combinations presents a number of...

Clinical isolates of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are known to differ from those associated with non-CF hosts by colony morphology, drug susceptibility patterns, and genomic hypermutability. Pseudomonas aeruginosa isolates from CF patients have long been recognized for their overall reduced rate of antimicrobial susceptibility, but their intraclonal MIC heterog...

The Brazilian Journal of Infectious Diseases 2008;12(2):105-106. © 2008 by The Brazilian Journal of Infectious Diseases and Contexto Publishing. All rights reserved. IOT – Institute of Orthopedics and Traumatology (Instituto de Ortopedia e Traumatologia), Clinical Hospital, School of Medicine, São Paulo University, started the administration of ertapenem in March 2006. The Clinical Hospital is ...

Dear Editor, Carbapenems are considered as the last resort of antibiotic for the treatment of infection but many Gram-negative organisms have developed resistance to this antibiotic through loss or alteration of outer membrane porin protein OprD, over-expression of efflux pump, hyperproduction of an AmpC-type-β-lactamase and/or carbapenemase.1 Carbapenemases are β-lactamases with catalytic effi...

Development is not restricted to so-called higher organisms. Developmental processes in bacteria include differentiation of a single cell, such as the swarmer-to-stalk transition by Caulobacter crescentus and spore formation by Bacillus subtilis. Other microbes, such as Myxococcus xanthus, produce specialized cells within a population to form sporulating fruiting bodies (19). As we learn more a...