Acquired and developmental apraxia of speech (AOS and DAS) are defined as disorders of the transition from an abstract phonological code into motor commands. However, the natural course of these disorders differs substantially because of the fundamental difference in the developmental stage at which the apraxia expresses itself. In normal and pathological development alike, development of langu...

Purpose The goal of this article is to introduce the pause marker (PM), a single-sign diagnostic marker proposed to discriminate early or persistent childhood apraxia of speech (CAS) from speech delay.

Motor apraxia was assessed in 25 patients with presumed dementia of the Alzheimer type and 23 patients with presumed multi-infarct dementia. Apraxia was common in both groups and was usually only mild. It correlated most strongly with language-related impairments in the Alzheimer group, as has been found in other patient groups, whereas in the group with multi-infarct dementia the pattern of co...

BACKGROUND Acute haemorrhagic leukoencephalitis (AHLE) is a rare and rapidly fatal disease of unknown aetiology. There is a paucity of literature on the presentation and management of this rare disease. CASE DESCRIPTION We report the case of a 33-year-old female presenting with headache and left-sided apraxia. Imaging revealed a right-sided white matter lesion with extensive cytotoxic oedema....

A 74-year-old right-handed woman without cognitive impairment suddenly developed nonfluent aphasia. Brain MRI showed acute infarction in the right frontal lobe and insula without involvement of the corpus callosum. A neurological examination demonstrated not only transcortical motor aphasia, but also ideomotor apraxia and right hand predominant constructional apraxia (CA). To date, right hand p...

Hereditary ataxias are a clinically and genetically heterogeneous family of disorders defined by the inability to control gait and muscle coordination. Given the nonspecific symptoms of many hereditary ataxias, precise diagnosis relies on molecular genetic testing. To this end, we conducted whole-exome sequencing (WES) on a large consanguineous Iranian family with hereditary ataxia and oculomot...

we present a 19-year-old patient with hematologic and neurologic manifestations associated with wilson’s disease. idiopathic thrombocytopenia was diagnosed in october 2009. bone marrow aspiration was normal. gradually her neurologic and psychiatric symptoms emerged, dysarthria, writing apraxia, learning difficulties, emotionalism and eventually dystonia of hands. the serum ceruloplasmin was low...

balint’s syndrome is a rare neurological disorder associated with bilateral parieto-occipital damage which was described by rezsö bálint in 1909.the syndrome is manifested clinically by the presence of a hemispatial negligence. the lesion is usually inside parietooccipital region bilaterally in most cases but may also be compromised angular convolutions, the dorsolateral area of the occipital l...