Introduction: Oral Squamous Cell Carcinoma (OSCC) represents approximately 96% of the entire oral cancers. Epithelial-mesenchymal transition (EMT) is a factor contributing to poor prognosis associated with OSCC. α-mangostin one xanthones which show anti-cancer activities against some types cancers and can suppress EMT-induced invasion by increasing E-cadherin expression. This study aimed identi...

BACKGROUND Downward trends have been observed in oral cancer incidence and mortality in the US over the past 30 years; however, these declines are not uniform within this population. Several studies have now demonstrated an increase in the incidence and mortality from oral cancers among certain demographic groups, which may have resulted from increased risks or risk behaviors. This study examin...

Structural racism negatively affects the health of Black populations in U.S. experience a higher burden oral diseases, such as tooth decay, periodontal disease, and pharyngeal cancers than other racial groups experience. Oral literature refers to inequities context social disadvantage. However, structural perpetuates those contributory disadvantages, inadequate access affordable housing, educat...

Oral cancer, mainly oral squamous cell carcinoma (OSCC), is one of the ten most common cancers in the world (Scully and Bedi, 2000) and the disease is predicted to increase in prevalence during the next several decades (Sciubba, 2001). In Thailand, the incidence for the disease is the highest in the southern part of the country where it is ranked the second in males and the sixth in females amo...

AIM OF THE STUDY Oral cancer ranks in the top three of all cancers in India and is quickly becoming a global health priority. More than 90% of oral and oropharyngeal cancers are squamous cell carcinoma. The purpose of this study was to document its incidence depending upon the involvement of different sites of oral cavity, and its variation with age and gender. MATERIAL AND METHODS Histopatho...

Objective. To evaluate oral cavity and pharynx cancer (OCPC) patterns by gender. Methods. We used Surveillance, Epidemiology, and End Results program data for 71,446 cases diagnosed during 1975-2008 to classify OCPC by anatomic subsite as potentially HPV-related or not, with oral tongue cancer considered a separate category. Results. Total OCPC rates among men were 2-4 times those among women. ...

BACKGROUND Over the next 20 years, oropharyngeal cancers (OPC) will represent the majority of head and neck cancers (HNCs) in the United States. It is estimated that human papillomavirus (HPV) may account for as much as 70% to 80% of OPCs in North America and in certain parts of Europe. It is hence crucial to understand the disease risk factors and natural history of oral HPV infections. We hyp...

Many types of cancers develop in the oral and maxillofacial region. Squamous cell carcinoma is the most common cancer and constitutes over 90 percent of these tumors. Malignant transformation is a genetic process, which later makes a phenotyping change at the cellular level. Some cancers such as oral squamous cell carcinomas (OSCCs) develop from pre-malignant lesions and conditions. Despite adv...

Parathyroid hormone-related protein (PTHrP) is detected in many aggressive tumors and involved in malignant conversion; however, the underlying mechanism remains obscure. Here, we identified PTHrP as a mediator of epidermal growth factor receptor (EGFR) signaling to promote the malignancies of oral cancers. PTHrP mRNA was abundantly expressed in most of the quiescent oral cancer cells, and was ...