The most common malignancy of the head and neck region is “oral squamous cell carcinoma” (OSCC) because its low survival rate increasing incidence in some geographic areas. The process invasion metastasis, which noted cancers, requires loss cell-to-cell attachment. It therefore important to identify a marker that would help identification lesions acquire ability transform into OSCC. Cell...

Oral carcinogenesis is a multi-step process. One possible step is the development of potentially malignant disorders known as leukoplakia and erytroplakia. The objective of this study was to use immunohistochemistry to analyze the patterns of expression of the cell-cycle regulatory proteins p53 and p16(INK4a) in potentially malignant disorders (PMD) of the oral mucosa (with varying degrees of d...

Oral cancer (OC) is the 6th most commonly reported malignancy worldwide.1 Among the various types of malignancy which occur in the oral cavity, 90% are oral squamous cell carcinomas.2 In India, due to varied cultural, ethnic, and geographic factors and the popularity of addictive habits, the frequency of OC is very high.3 It positions number one in terms of incidence among men and third among w...

OBJECTIVES The aim of this work was to assess risk habits, clinical and cellular phenotypes and TP53 DNA changes in oral mucosa samples from patients with Oral Potentially Malignant Disorders (OPMD), in order to create models that enable genotypic and phenotypic patterns to be obtained that determine the risk of lesions becoming malignant. STUDY DESIGN Clinical phenotypes, family history of c...