In order to determine whether an adrenergic mechanism is involved in the secretion of growth hormone and insulin, the effect of adrenergic-blocking or -stimulating agents on plasma human growth hormone (HGH), immunoreactive insulin, blood free fatty acids (FFA), and glucose levels was studied in normal human subjects. The intravenous infusion of propranolol, a beta adrenergic-blocking agent, ca...

Today, in adult cardiology, the efficacy of beta blockers in patients with congestive heart failure is well established. Beta blockers, as a drug class, provide mortality benefits in comparison with placebo, or standard treatment, in patients with mild to severe heart failure. However, 40 years after Waagstein's first reports in adults and 20 years after our reports in infants with congenital h...

Aim For several drugs available as licensed liquids, multiple concentrations exist. Four different propranolol are available: 1 mg/mL, 2 8 mg/mL and 10 mg/mL. Existence of increases the chance dosing errors. The Neonatal Paediatric Pharmacists Group (NPPG) Royal College Paediatrics Child Health (RCPCH) recommend standard for some unlicensed liquid medicines , but no such recommendation exists p...

Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed...

The effects on ventricular arrhythmia of acebutolol were compared with those of propranolol in 31 patients who averaged more than 30 ventricular premature complexes (VPCs) per hour during 72 hours of ambulatory ECG recording during a placebo-controlled baseline period. The study consisted of an initial 2week placebo-controlled baseline period followed by two 6-week double-blind treatment period...

The role of renal prostaglandins and the adrenergic nervous system in the control of renin release was studied in conscious dogs with thoracic caval constriction. Indomethacin reduced plasma renin activity (PRA) in intact animals with thoracic caval constriction by 43% but failed to change PRA after surgical renal denervation and during chronic propranolol administration; adrenergic blockade re...