There are about 600 million betel quid (BQ) chewers in the world. BQ chewing is associated with increased incidence of oral cancer and submucous fibrosis. In this study, areca nut (AN) extract (200-800 microg/ml) induced the prostaglandin E(2) (PGE(2)) production by 1. 4-3.4-fold and 6-keto-PGF(1 alpha) production by 1.1-1.7-fold of gingival keratinocytes (GK), respectively, following 24 h of e...

Introduction: Oral Submucous fibrosis (OSMF) is well recognized as one of the most common potentially malignant disorder of the oral mucosa in India related to chewing of areca nut products and characterized by mucosal rigidity of varying intensity caused by fibroelastic changes of the juxta – epithelial layer, resulting in a progressive inability to open the mouth. Ultrasonography (USG) is a n...

Although oral submucous fibrosis (OSF) is the most common precancerous lesion of the oral cavity in Southeast Asia where the habit of betel quid (BQ) chewing is popular, its molecular biological properties are largely unknown. The aim of this study was to identify the genes responsible for its pathogenesis and malignant transformation using oligonucleotide microarray. The expression profiles of...

BACKGROUND Evaluation of molecular pathology markers using a computer-aided quantitative assessment framework would help to assess the altered states of cellular proliferation, hypoxia, and neoangiogenesis in oral submucous fibrosis and could improve diagnostic interpretation in gauging its malignant potentiality. METHODS Immunohistochemical (IHC) expression of c-Myc, hypoxia-inducible factor...

‘Vidari’ is a crippling fibrotic disorder affecting mouth commonly seen in India and South East Asia. It’s always optimum highly desirable to beat oral submucous fibrosis(OSMF) before it becomes cancer. OSMF huge dilemma for clinicians worldwide specifically south east Asia due elusive pathogenesis. The main characterstic of the build up fibrous tissue sub mucosal layer mouth, which can lead lo...

Background: Oral cancer is one of the most significant reasons death in India. The quantitative and qualitative assessment AgNORs parameters has been used oncology for both diagnostic prognostic objectives. number distribution AgNOR nucleus (configuration) were helpful detecting predicting prognosis various neoplasias. Aim: To assess biologic aggressiveness leukoplakia, oral submucous fibrosis ...

BACKGROUND Oral Submucous fibrosis (OSMF) is a common potentially malignant disease, which is characterized by generalized fibrosis of the oral soft tissues. It is due to disproportion in the collagen deposition and degradation. The excess deposition of collagen results in juxta epithelial fibro elastic changes and epithelial atrophy. Neoplastic changes in the epithelium usually precede the cha...