In daily clinical practice, the frequency of painful crises (pain rate) is an important parameter of sickle cell disease severity. We assessed the prevalence of sickle cell disease-related organ damage and complications and their relation to pain rate. Organ damage and history of vaso-occlusive complications were obtained via systematic screening of consecutive patients and by chart review. In ...

Background: Recent evidence supports that the prehypertension is associated with target organ damage, though there is lack of information regarding common carotid artery intima media thickness (CIMT) in prehypertensive individuals. We aimed to study the role of prehypertension in target organ damage in the form of CIMT. Methods: Carotid CIMT was measured by B-mode ultrasonography by an experien...

Volatile anesthetics are known to have immunomodulatory effects in conditions of organ injury. A recent study in an experimental sepsis model has shown remarkably improved survival when mice were exposed to volatile anesthetics. In the present study, we show that hexafluoroisopropanol - a water-soluble primary sevoflurane metabolite - has beneficial effects on the overall survival in a murine m...

The aim of the study was to determine the prevalence and relation between urinary albumin excretion (UAE) and target organ damage (Left ventricular hypertrophy (LVH), retinopathy and stroke) in patients with essential Hypertension. We evaluated 120 patients of essential hypertension (HT), prevalence of UAE, and its correlation to target organ damage (TOD) were determined. UAE was assessed accor...

Parasympathetic nerves are a vital component of the progenitor cell niche during development, maintaining a pool of progenitors for organogenesis. Injured adult organs do not regenerate after parasympathectomy, and there are few treatments to improve organ regeneration, particularly after damage by therapeutic irradiation. Here we show that restoring parasympathetic function with the neurotroph...