نتایج جستجو برای: organizational linkers
تعداد نتایج: 94667 فیلتر نتایج به سال:
BACKGROUND Targeted liposome-polycation-DNA complex (LPD), mainly conjugated with antibodies using functionalized PEG derivatives, is an effective nanovector for systemic delivery of small interference RNA (siRNA). However, there are few studies reporting the effect of different conjugation linkers on LPD for gene silencing. To clarify the influence of antibody conjugation linkers on LPD, we pr...
MOTIVATION Disordered flexible linkers (DFLs) are disordered regions that serve as flexible linkers/spacers in multi-domain proteins or between structured constituents in domains. They are different from flexible linkers/residues because they are disordered and longer. Availability of experimentally annotated DFLs provides an opportunity to build high-throughput computational predictors of thes...
PolyMOFs prepared from mixtures of multivalent polymer linkers and free display tunable surface areas improved CO 2 uptake compared to native MOF-5 polyMOF-5.
We extend Wertheim’s thermodynamic perturbation theory to derive the association free energy of a multicomponent mixture for which double bonds can form between any two pairs molecules’ arbitrary number bonding sites. This generalization reduces in limiting cases prior theories that restrict at most one pair sites per molecule. apply new an associating colloidal particles (“colloids”) and flexi...
We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-synthetic hydrogels are form-stable, can withstand repeated stress, have a large linear-elastic rang...
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