The bifunctional thiourea-tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of alpha-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.

Chitosan, which is derived from the biopolymer chitin, can be readily dissolved in different ionic liquids. The resulting homogeneous solutions were applied in an asymmetric Aldol reaction. Depending on the type of ionic liquid used, high asymmetric inductions were found. The influence of different additives was also studied. The best results were obtained in [BMIM][Br] without an additive.

A practical, cost-saving tagging approach is developed which takes advantage of the hydrophobicity of trifluoromethyl groups, exemplified by the application and recovery of a CBS precatalyst using tuned aqueous-organic media with minimum 50% water content.

Hydrogen bonding phase-transfer catalysis offers a convenient solution to activate safe and economical metal alkali fluorides for enantioselective nucleophilic fluorination. Herein, we demonstrate the scalability of this protocol with fluorination 200 g racemic trans-N,N-dibenzyl-2-bromocyclohexan-1-amine in mechanically stirred 1 L glass reactor using 0.5 mol % bis-urea organocatalyst. In thes...

Michael addition is one of the most important carbon–carbon bond formation reactions. In this study, an (R, R)-1,2-diphenylethylenediamine (DPEN)-based thiourea organocatalyst was applied to asymmetric nitroalkenes and cycloketones produce a chiral product. The primary amine moiety in DPEN reacts with ketone form enamine activated through hydrogen between nitro group ?, ?-unsaturated nitroalken...

Electrochemical synthesis has been rapidly developing over the past few years. Here, we report a practical and eco-friendly electrocatalytic isomerization of allylic alcohols to their corresponding carbonyl compounds. This reaction can be carried out in undivided cells without addition external chemical oxidants metal catalysts. Moreover, this features broad substrate scope including challengin...