A strained 1-phenyl-2,3-dimethylphosphirene undergoes anionic ring-opening polymerization upon initiation with n-butyl lithium at ambient temperature to yield polyvinylenephosphine, an unsaturated organophosphorus polymer.

Reaction of a cyclophosphinophosphonium cation with neat MeOTf represents a general and high-yield synthetic approach to dications enabling the isolation of the first derivatives of 2,4,5-triphosphino-1,3-diphosphonium as bis-triflate salts.

Enzyme sensor for organophosphorus insecticides organophosphorus hydrolase in a polymer membrane on a pH sensor is used to catalyse the hydrolysis of compounds with phoshate ester functionality. The detected [H+] change is proportional to the concentration of the phosphate ester insecticide. This is a good example of the use of an enzyme to give selectivity to a specific class of compounds. Unf...

Organophosphorus Pesticide Poisoning Self-poisoning with Organophosphorus (OP) pesticides is a major problem across the Asia Pacific region. They cause the majority of poisoning deaths in India, except in some northern areas where aluminium phosphide predominates. There is no effective treatment for aluminium phosphide poisoning; in contrast, moderately effective treatments and antidotes exist ...

The paper by Aardema and colleagues in this issue of the Netherlands Journal of Medicine illustrates well the problems that clinicians face with organophosphorus pesticide self-poisoning. Yet the toxicological literature’s image of this poisoning is beguilingly simple. Ingestion of an organophosphorus pesticide results in inhibition of acetylcholinesterase. The resulting build up of acetylcholi...

Most organophosphorus esters are direct inhibitors or are rapidly converted to inhibitors of acetylcholinesterase (AChE, EC 3.1.1.7) (1-3). Some of these compounds produce a more persistent effect: delayed neurotoxicity. In humans, organophosphorus ester-induced delayed neurotoxicity (OPIDN) results in a flaccid paresis which develops distally in the legs and spreads to the hands and thighs. In...

objective: organophosphorus (ops) compounds are widely used in many pesticides, insecticides and chemical nerve agents. these compounds are hazardous for humans and the environment. organophosphate hydrolase (oph) is a homodimeric protein initially isolated from pseudomonas diminuta mg and flavobacterium species. this enzyme is able to degrade a broad spectrum of toxic ops compounds. using immo...

A new biometallization route for detecting low levels of organophosphorus nerve agents based on organophosphorus-hydrolase (OPH)-stimulated formation of cupric-ferrocyanide (CuFeCN) nanoparticles is described. The growth and accumulation of these nanoparticles onto the surface of carbon paste electrodes, coupled with their favorable redox activity, allow the amplified electrochemical detection ...

A review of nineteen hundred cases of acute poisoning admitted to the Intensive Care Unit shows that poisoning was responsible for 40% of the emergencies treated at this Unit, between 15th January, 1976 to 15th November, 1985. Comparing our data with Western figures, it was noted that the pattern of poisoning in our Country is considerably different from that in the West. Organophosphorus insec...

Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development methods for environmental remediation and passivation has been ongoing years. However, little progress made in therapeutic development exposure victims. Given the postexposure behavior OPA materials enzymes such as acetylcholinesterase (AChE), electr...