from 1951 to 1972 it was my good fortune to meet most of the leading medical research workers of that period. Some of their published papers do not give all the details of what led to their results so herewith an attempt to complete the record. The late Sir Christopher Andrewes, regarded by many as the founding father of virology research, spent years trying to isolate the influenza virus, whic...

We evaluated 49 swine industry workers and 79 nonexposed controls for antibodies to swine influenza viruses. Multivariate modeling showed that workers who seldom used gloves (odds ratio [OR] 30.3) or who smoked (OR 18.7) most frequently had evidence of previous H1N1 swine virus. These findings may be valuable in planning for pandemic influenza.

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Antibody directed against the neuraminidase of an influenza virus did not prevent attachment of the virus to red cells, but strongly inhibited elution of the virus from these cells. The virus used in these experiments had approximately 5o0 enzyme antigenic sites on the surface of each particle. In the presence of sufficient antibody to combine with all of these sites there was no measurable elu...

BACKGROUND In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-depend...

The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, the genesis of progeny virions has been more difficult to follow, mainly because of difficulties inherent in fluorescent labeling of flu proteins in a manner compatible with l...

Influenza circulation and mortality impact in tropical areas have not been well characterized. The authors studied the seasonality of influenza throughout Brazil, a geographically diverse country, by modeling influenza-related mortality and laboratory surveillance data. Monthly time series of pneumonia and influenza mortality were obtained from 1979 to 2001 for each of the 27 Brazilian states. ...

In this paper we propose the use of a random network model for simulating and understanding the epidemics of influenza A(H1N1). The proposed model is used to simulate the transmission process of influenza A(H1N1) in a community region of Venezuela using distributed computing in order to accomplish many realizations of the underlying random process. These large scale epidemic simulations have re...

Introduction Every year, circulating influenza viruses generate a significant number of deaths. During the 2009 pandemic influenza A(H1N1), a national non mandatory surveillance system of severe influenza cases admitted to intensive care units(ICU) was set up in France. This surveillance is regionally driven by the regional offices (CIRE) of Santé publique France, the French Public Health Agenc...