PURPOSE Dynamic tracer behavior in the human body arises as a result of continuous physiological processes. Hence, the change in tracer concentration within a region of interest (ROI) should follow a smooth curve. The authors propose a modification to an existing slow-rotation dynamic SPECT reconstruction algorithm (dSPECT) with the goal of improving the smoothness of time activity curves (TACs...

PURPOSE Talc pleurodesis (TP) is employed worldwide for the management of persistent pneumothorax or pleural effusion, particularly of malignant origin. However, there are very little available data on (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography ((18)F FDG PET/CT) response evaluation in malignant pleural mesothelioma (MPM) patients treated with TP and chemotherapy....

List-mode processing is an efficient way of dealing with the sparse nature of PET data sets, and is the processing method of choice for time-of-flight (ToF) PET. We present a novel method of computing line projection operations required for list-mode ordered subsets expectation maximization (OSEM) for fully 3-D PET image reconstruction on a graphics processing unit (GPU) using the compute unifi...

Incorporation of a resolution model during statistical image reconstruction often produces images of improved resolution and signal-to-noise ratio. A novel and practical methodology to rapidly and accurately determine the overall emission and detection blurring component of the system matrix using a printed point source array within a custom-made Perspex phantom is presented. The array was scan...

Zusammenfassung: Das Auflösungsvermögen der Positronen-EmissionsTomographie resultiert aus einem Zusammenspiel verschiedenster Parameter, die in ihrer Summe Grenzen der Detektierbarkeit kleiner Objekte festlegen. Diese Grenzen sollten an Hand von Simulationen mit einem Software-Phantom in Abhängigkeit von Akquisitionszeit und Aktivitätskontrast Objekt / Hintergrund ermittelt werden. Die Rekonst...

Abbreviations 2D, 3D 2-dimensional, 3-dimensional CZT cadmium zinc telluride EKG electric signal from the heart FBP filtered backprojection FOV field-of-view GE General Electric Ge(Li) germanium detector doped with lithium MLEM maximum likelihood expectation maximization NaI(Tl) sodium iodine doped with thallium NM nuclear medicine OSEM ordered subset expectation maximization PET positron emiss...

PURPOSE The Ingenuity time-of-flight (TF) PET/MR is a recently developed hybrid scanner combining the molecular imaging capabilities of PET with the excellent soft tissue contrast of MRI. It is becoming common practice to characterize the system's point spread function (PSF) and understand its variation under spatial transformations to guide clinical studies and potentially use it within resolu...

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA , USA We describe a novel semi-automated pipeline which integrates advanced data analysis tools for MR and PET with advanced PET reconstruction correction methods (partial volume effect correction [PVC], motion correction [MC], attenuation corr...