PURPOSE The purpose of this study was to assess the effect(s) of platelet-rich plasma (PRP) on osteochondral donor site healing in a rabbit model. METHODS Osteochondral donor sites 3 mm in diameter and 5 mm in depth were created bilaterally on the femoral condyles of 12 New Zealand White rabbits. Knees were randomized such that one knee in each rabbit received an intra-articular injection of ...

INTRODUCTION Osteochondral grafts have become popular for treating small, isolated and full-thickness cartilage lesions. It is recommended that a slightly oversized, rather than an exact-sized, osteochondral plug is transplanted to achieve a tight fit. Consequently, impacting forces are required to insert the osteochondral plug into the recipient site. However, it remains controversial whether ...

BACKGROUND Current treatments for osteochondral injuries often result in suboptimal healing. We hypothesized that the combination of hyperbaric oxygen (HBO) and fibrin would be superior to either method alone in treating full-thickness osteochondral defects. METHODS Osteochondral repair was evaluated in 4 treatment groups (control, fibrin, HBO, and HBO+fibrin groups) at 2-12 weeks after surgi...

Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. Our aim was to investigate the feasibility of MSC-like cells originated from i...

BACKGROUND To determine the efficacy of different antiseptic solutions (Control group (I), Antibiotic solution (II), Chlorhexidine 0.4% (III), and povidone - iodine 10% (IV)) in sterilizing contaminated osteochondral plugs. METHODS Under sterile conditions, the femoral head and condyles of 20 rabbits were removed and cut into equal osteochondral pieces. A total of 200 osteochondral specimens ...

Background Focal chondral lesion is a common cause of chronic wrist pain. The best treatment remains unknown. We have developed a technique of arthroscopic transplantation of an osteochondral autograft from the knee joint to the distal radius with satisfactory clinical results. Materials and Methods Between December 2006 and December 2010, four patients (average age 31 years) with posttraumatic...

Introduction: Subchondral bone (SB) micro-fracture due to high-impact loading is a key factor leading to post traumatic knee osteoarthritis [1]. The apparent-level impact mechanics of SB has been previously investigated using mechanical tests [2]. However, to investigate the osteochondral injuries, the tissue-level impact mechanics, especifically, the mechanical parameters associated with SB mi...

Background: Autogenous osteochondral grafting of articular defect in weight-bearing surface of large joints has proven to be a proper biomechanical and physiological solution for localized full-thickness defects.Objective: To study the gross and histopathological results of mosaicplasty in an animal model (sheep’s medial femoral condyle), evaluating the factors of defect and graft size, assessi...

Background: Although some surgical techniques have been described for the operative treatment of unstableOsteochondritis dissecans (OCD) of the knee, outcomes are variable and are not satisfying totally. The aim of thepresent study is to evaluate the outcomes of autogenous osteochondral grafting for OCD of the knee.Methods: In a case series study, from June 2014 to July 2015, ...

Surgical treatment of posteromedial talar dome lesions is frequently necessary for Berndt and Harty grade IV osteochondral defects and nondisplaced osteochondral fragments resistant to conservative modalities. When operative intervention is indicated, the approach and management can be complicated by the location and extent of the injury. The operative technique we advocate allows direct exposu...