Multiple studies have recently demonstrated the oncogenic property of URI (or RMP, a member of the prefoldin family of molecular chaperones) during progression of hepatocellular carcinoma, ovarian cancer, and possibly prostate cancer. Most recently, we have shown that URI/RMP is up-regulated in cervical cancer, another reproductive system tumor beside ovarian and prostate cancers. To investigat...

A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC(...

Secondary metastatic tumours of the uterine cervix are rare. There have been no reports of duodenal cancer metastasizing to the uterine cervix. Here we present a rare case of an extra-ampullary duodenal adenocarcinoma that has metastasized to the uterine cervix. The patient was a 71-year-old woman who had surgery for an extra-ampullary duodenal adenocarcinoma five years previously. Follow-up ex...

Prophylactic salpingo-oophorectomy (PO) entails removal of the ovaries prior to the clinical occurrence of cancer. Prophylactic removal of the ovaries, during hysterectomy or other abdominal surgery, to prevent ovarian cancer in postmenopausal women was popularised in the 1940s by Crossen, who stated “the involuting ovaries have fulfilled their reproductive and endocrine function. They are....v...

Background: Ovarian cancer is third gynecologic after uterine and cervical . It heterogeneous disease with different in clinical features outcome. a group of many subtypes variation biological that lead to differences response treatments, survival recurrence rates. Aim: This study aims detect the frequency histological types primary malignant ovarian tumors find it's clinicopathological correla...

Monoclonal antibody SM 92 is involved in the immunophenotype of gastrointestinal and liver cells, SM 43 in ovarian cells, and SM 13 in lung cells. Based on a study of 61 breast adenocarcinoma patients, we found that tumors reacting with SM 92 appear associated with liver metastases, SM 43 with ovarian metastases, and SM 13 with lung metastases. These associations are highly significant. They le...