premature ovarian failure (pof) is a heterogeneous syndrome with several causative factors. autoimmune mechanisms are involved in pathogenesis of 4-30 % of pof cases. the present review focuses on the role of autoimmunity in the pathophysiology of pof. the evidences for an autoimmune etiology are: demonstration of ovarian autoantibodies, the presence of lymphocytic oophoritis, and association w...

background: previous studies have reported the antifertility activities of sulfonamides. this study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats. methods: a total of 54 rats were randomly divided into 9 groups (n=6) . group i served as the control and group ii (vehicle) received saline. other groups, iii to ix,...

background: the best management for an ovarian mass is provided by appropriate prediction of malignancy. the aim of our study is to construct and validate a new malignancy probability score based on four simple sonographic findings and age. methods: in a cross sectional study; histopathological files of 3303 ovarian mass patients and tertiary hospitals, have reviewed within 6 years (2000-2006)....

abstract ovarian tissue freezing or cryopreservation might be the only acceptable method for preserving the young women fertility, before radiotherapy or chemotherapy. this technology might be used for patients with recurrent ovarian cysts or endometriosis, without ovarian stimulation. many efforts have made to improve cryopreservation conditions that should be seriously considered for cancer p...

The epithelial ovarian carcinomas, which make up more than 85% of human ovarian cancer, arise in the ovarian surface epithelium (OSE). The etiology and early events in the progression of these carcinomas are among the least understood of all major human malignancies because there are no appropriate animal models, and because methods to culture OSE have become available only recently. The object...

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to d...

Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development ...

Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with defined mutations in Wnt pathway components that result in dysregulated β-catenin-mediated gene transcription. Although Wnt pathway mutations are rare in epithelial ovarian cancer (with the exception of the endometrioid histotype), accumula...

In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and...

in the present report, diagnosis and treatment of a case with follicular ovarian cysts in a 5-year-old persian queen cat is described. in response to palpation of spines, the queen cat presented herself in lordosis and danced up and down with her rear legs. trans-abdominal ultrasonography examination showed 2 cysts  in the left ovary of the queen. serum estrogen assay indicated elevated level o...