we present 2 cases of likely rare event. in case 1, 3rd degree consanguineous marriage revealed inv(6) with same break points in parents who were found to be phenotypically normal. the same inv(6) being inherited in progeny but presented with low amh (anti mullerian hormone) and high level of fsh (follicular stimulating hormone) leading to polycystic ovarian syndrome/premature ovarian failure. ...

Background: Mesenchymal stem cells (MSCs) can be used to treat premature ovarian failure (POF). Different methods have already been applied to detect MSCs in tissues. This study aimed to investigate the quantitative distribution of CM-DiI-labeled human umbilical cord vein MSCs (hUCV-MSCs) in different regions of the ovarian tissue of the cyclophosphamide ( CTX )-induced POF in mice. Methods: Ad...

Background Fertility preservation for female cancer patients prior to cancer therapy has emerged as an essential component of comprehensive patient care. In the US, approximately 6% of women diagnosed with invasive cancer between 2007 and 2011 that were under 45 years old. The incidence of cancers in reproductive age women signifies a need for fertility preservation options and this need is inc...

A case of a patient with premature ovarian failure (POF) is discussed. Ovulation failed to occur for 5 years by gonadotropin-releasing hormone agonist (GnRHa) and human menopausal gonadotropin (hMG) treatment following estrogen-progesterone replacement therapy. After laparoscopic ovarian biopsy, ovulation was successfully induced by hMG, although gonadotropins were not suppressed enough, and th...

BACKGROUND Young cancer patients may occasionally face infertility and premature gonadal failure. Apart from its direct effect on follicles and oocytes, chemotherapy may induce ovarian toxicity via an impact on the entire ovary. The role of doxorubicin in potential ovarian failure remains obscure. Our intention was to elucidate doxorubicin-related toxicity within ovaries. METHODS Female mice ...

A woman with metastatic ovarian carcinoma developed postoperative respiratory failure due to interstitial lung metastases demonstrated by bronchoalveolar lavage. After chemotherapy, she was able to be removed from mechanical ventilation and has shown progressive resolution of her interstitial lung disease. Metastatic ovarian carcinoma can be a treatable etiology of life-threatening interstitial...

The present study was conducted to compare between the therapeutic efficacies of human amniotic membrane-derived stem cells (hAM-MSCs) vs. adipose tissue derived stem cells (AD-MSCs) in cyclophosphamide (CTX)-induced ovarian failure in rats. Forty-eight adult female rats were included in the study; 10 rats were used as control group. Thirty-eight rats were injected with CTX to induce ovarian fa...

introduction: primary ovarian failure (pof) is a syndrome composed of amenorrhea, estrogen deficiency and follicular stimulating hormone (fsh) of menopausal ranges in young women. in this article, we report a case of primary amenorrhea that presented with full term pregnancy.case presentation: a 29-year old woman with a history of primary amenorrhea attended hospital with full term pregnancy. s...

pelvic inflammatory disease (pid) is a rare complication of transvaginal oocyte retrieval. it may result in failure of assisted reproductive techniques (art). during a 7 years period, 5958 transvaginal ultrasound-guided oocyte retrievals resulted in 10 cases of acute pid. eight out of 10 patients were diagnosed infertile because of endometriosis. two patients had mild ovarian, 3 had stage iii, ...

Advances in the diagnosis and treatment of cancer have resulted in a growing population of adolescent and adult long-term survivors of malignancies with infertility problems due to induced premature ovarian failure. Although several options are currently available to preserve fertility in cancer patients, cryopreservation of ovarian tissue is the only option available for prepubertal girls and ...