OBJECTIVE There is an increasing evidence that genetic factors play a role in the etiology of malignant tumors. Mutations of BRCA1 and BRCA2 genes are responsible for an increased risk of ovarian cancer. The role of mutations in NOD2 gene in this type of neoplasm is still under investigation. THE AIM The aim of this study was to determine: 1. incidence of NOD 2 3020insC constitutional mutatio...

CA-125 is a serum marker that raised in various malignant and non- conditions, but very high rise (>1000 U/mL) almost always suggests ovarian malignancy. Here we report rare case of tuberculous peritonitis 58-year-old woman who presented with gradually progressive abdominal distension weight loss, her level was >1000 U/mL. Initially suspecting this as malignancy, ascitic fluid study to de...

Growing teratoma syndrome (GTS) is a rare clinical entity first described by Logothetis et al in 1982. Although it is unusual for GTS to be located in the ovary, this report is of a case of an adolescent girl who underwent a complete surgical resection of the mass. Histopathology confirmed only an immature teratoma had originated from the ovary and so she received adjuvant chemotherapy with ble...

Abstract Background Inadequacy of effective sensitive and specific screening modalities results in late-stage diagnosis ovarian cancer. Cancer Antigen-125 (CA-125) individually possesses limited specificity for differentiating adnexal masses. The present study aimed to evaluate the Human Epididymis Protein 4 (HE4), Risk Ovarian Malignancy Algorithm (ROMA), Index (RMI) ameliorating sensitivity b...

a 22-year-old patient with 9 months of amenorrhea and a huge abdominal swelling was admitted to our institution with an ultrasonography report of a multiloculated cystic space-occupying lesion, almost taking up the whole abdomen (probably of ovarian origin), along with a single live intrauterine fetus. she delivered vaginally a boy baby within 4 hours of admission without any maternal complicat...

OBJECTIVE Benign massive ovarian oedema is a rare clinical entity arising from the ovaries, and it poses a significant clinical challenge as it can be easily mistaken for neoplasm. Due to the lack of pathognomonic clinical features or characteristic hallmarks on non-invasive diagnostic modalities and the dependence on the final histopathology, the efforts of the surgeon have been deviated from ...

Introduction Gliomatosis peritonei (GP) is characterized by the presence of benign, mature glial implants in peritoneum or omentum. Aim Understanding unusual findings with clear knowledge pathological comparisons makes diagnosis more reliable and guides future treatment. Case study This a case 70-years-old lady, post-menopausal, who presented abdominal mass which progressively increased size fo...

Background: Ovarian neoplasm is one of the most complex tumours of women in terms of histogenesis, clinical behaviour and malignant potentiality and is the third most common cancer of female genital tract. Estrogen and progesterone hormones and their receptors are thought to be involved in process of tumour genesis in ovarian cancers. The objective of this study was to evaluate histopathology o...