Brf1 (TFIIB-related factor 1) is a transcription factor, which specifically modulates the of RNA polymerase III-dependent genes (RNA Pol III genes), such as tRNAs and 5S rRNA. The products rRNA will be changed with alteration expression. Whereas deregulation are tightly associated cell proliferation transformation, tumorigenesis. In recent years, emerging studies indicate that expression increa...

Purpose: To investigate the mechanism of microRNA-124 action on neuroblastoma apoptosis induced by sevoflurane.
 Methods: MiR-124 expression was assessed in a cell line (SMS-KAN) using quantitative reverse transcription polymerase chain reaction (qRT-PCR). The role miR-124 sevoflurane anesthesia-induced studied activity and analysis 3-(4, 5-dimethylthiazolyl-2-yl)-2-5 diphenyl tetrazolium ...

Cembranoids produced by tobacco glandular trichomes have bioactivities in resistance to insect pests and pathogens. Cembratrien-ol synthase (CBTS) plays a key role the biosynthesis of cembranoids directly determines cembranoid content tobacco. This study examined effect changing CBTS1 expression on pest Spodoptera frugiperda oomycete pathogen Phytophthora nicotianae. The CDS sequence was cloned...

Oxidative stress is proposed to be involved in nonalcoholic fatty liver disease (NAFLD). However, antioxidant therapy results controversial outcomes. Therefore, we generated a new antioxidant/NAFLD mouse model, Lias High/High Lepr db/db mice, by crossbreeding an obesity with overexpression of lipoic acid synthase gene ( ) and having increased endogenous capacity, investigate whether the model c...

Purpose: To investigate the effect of forkhead box N3 (FOXN3) protein on doxorubicin (DOX) resistance urothelial carcinoma (BLCA).
 Methods: Bioinformatics prediction and immunoblotting were used to evaluate FOXN3 expression in BLCA tissues cells. The overexpression was achieved by cell transfection. effects DOX apoptosis determined immunoblotting, assay, flow cytometry, while applied SIRT...

Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...