Since 1981 AIDS has illuminated, like a roving searchlight, a series of ethical questions, which extend far beyond the apparently narrow limits of one disease. It has revealed, one by one, human attitudes and behaviours that were previously unquestioned, or unobserved based on unidentified but shaky pre-suppositions. This commentary oVers two contrasting perspectives on the problems facing deve...

The importance of tectonics and fluid flow in controlling cold seep habitats has long been appreciated at convergent margins but remains poorly understood in strike-slip systems. Here we present geophysical, geochemical, and biological data from an activemethane seep offshore fromDelMar, California, in the inner California borderlands (ICB). The location of this seep appears controlled by local...

Recombination, in the form of cross-overs (COs) and gene conversion (GC), is a highly conserved feature of meiosis from fungi to mammals. Recombination helps ensure chromosome segregation and promotes allelic diversity. Lesions in the recombination machinery are often catastrophic for meiosis, resulting in sterility. We have developed a visual assay capable of detecting Cos and GCs and measurin...

Introducing cross-functional teams is one way of reducing the manual hand-overs in a project [1]. A challenge these teams face in large-scale software development is that the items pulled from the backlog refer to a product that has evolved in a way that makes their understanding of the system obsolete. In order to quickly understand the product and the impact of implementing the backlog item i...

This paper develops a Twenty20 cricket simulator for matches between sides belonging to the International Cricket Council. As input, the simulator requires the probabilities of batting outcomes which are dependent on the batsman, the bowler, the number of overs consumed and the number of wickets lost. The determination of batting probabilities is based on an amalgam of standard classical estima...

Homology-facilitated illegitimate recombination has been described in three naturally competent bacterial species. It permits integration of small linear DNA molecules into the chromosome by homologous recombination at one end of the linear DNA substrate, and illegitimate recombination at the other end. We report that homology-facilitated illegitimate recombination also occurs in Escherichia co...

Size matters. Human perception most naturally relates relative extent, area or volume to importance, nearness and weight. Reversely, conveying importance of something by depicting it at a different size is a classic artistic principle, in particular when importance varies across a domain. One striking example is the neuronal homunculus; a human figure where the size of each body part is proport...

We present a mean-field dynamical theory for single semiflexible polymers which can precisely capture, without fitting parameters, recent fluorescence correlation spectroscopy results on single monomer kinetics of DNA strands in solution. Our approach works globally, covering three decades of strand length and five decades of time: it includes the complex cross-overs occurring between stiffness...

We present a mean-field dynamical theory for semiflexible polymers which can precisely capture, without fitting parameters, recent fluorescence correlation spectroscopy results on single monomer kinetics of DNA strands in solution. Our approach works globally, covering three decades of strand length and five decades of time: it includes the complex cross-overs occurring between stiffness-domina...

The food-energy-water (FEW) nexus provides leeway into the lateral transmission of price volatilities within sectors. problem is that any inflationary tendencies in one FEW sectors will have direct and indirect effect on others. objective study was to ascertain relationship between inflation food, energy water, determine whether there were spill-overs, South Africa. Monthly consumer indices for...