Abstract An improved chemical process has been developed for the synthesis of (S,S)-DACH-Ph Trost ligand. The amidation 2-diphenylphosphinylbenzoic acid and (S,S)-diaminocyclohexane is promoted by stoichiometric CDI catalytic imidazole hydrochloride. resulting product, ligand, isolated as a white solid in 80% yield with >99% ee simple filtration without column chromatography. current facile ...

The scope of the NHC-redox amidation has been expanded to include a variety of α,β-unsaturated aldehydes, including α-fluoro α,β-unsaturated aldehydes which give rise to enantioenriched α-fluoroamides in good to excellent yield and enantioselectivity (up to 97% ee). Enantioenriched amines may be elaborated to either diastereomer of the product in high diastereoselectivity (up to 99:1). Function...

A highly enantioselective organocatalytic Wolff rearrangement–amidation–Michael– hemiaminalization stepwise reaction is described involving a cyclic 2-diazo-1,3-diketone, primary amine and α,β-unsaturated aldehyde. Product stereocontrol can be achieved by adjusting the sequence of steps in this one-pot multicomponent reaction. This approach was used to synthesize various optically active spiroc...

Benzoyl azides were used for the direct and atom economic C–H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroarylor alkenyl acyl azides and has a wide scope for hete...

Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for he...

Bio-based surfactants have attracted increasing attention due to their renewable resources and excellent surface properties. In this study, a novel bio-based sulfonic zwitterionic surfactant (BSZS) derived from transgenic soybean oil was prepared using a simple reaction route with two steps of the amidation and quaterisation. The bio-based sulfonic zwitterionic surfactant showed a critical mice...