نتایج جستجو برای: oxindole
تعداد نتایج: 442 فیلتر نتایج به سال:
In the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. Then, the applicability of the synthesized catalyst cellulose bonded N-propyl diethylene triamine (CBPDETA) was tested for the synthesis of oxindole derivatives, an important class of potentially bioactive compounds. A various series o...
<p>In silico study by molecular docking, drug discovery, and virtual screening are useful for obtaining compounds with promising biological activity. The force fields energy minimization in docking is the overall process to produce better geometry estimation ligand-receptor affinity. In this study, divide conquer algorithm based on Mikowski matrix MarvinSketch conjugate gradient of Open B...
A novel magnetically immobilized polyethyleneimine (PEI) fabricated by covalently anchoring on silica coated Fe3O4 nanoparticles (PEI@Si-MNPs) was prepared. The synthesized catalyst was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), X-ray powder diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). The immobili...
Abstract Aliphatic esters are essential constituents of biologically active compounds and versatile chemical intermediates for the synthesis drugs. However, their preparation from readily available olefins remains challenging. Here, we report a strategy to access aliphatic through photocatalyzed alkoxycarbonylation reaction. Alkyloxalyl chlorides, generated in situ corresponding alcohols oxalyl...
Anticancer role of andrographolide is well documented. To find novel potent derivatives with improved cytotoxicity than andrographolide on cancer cells, two series of di-spiropyrrolidino- and di-spiropyrrolizidino oxindole andrographolide derivatives prepared by cyclo-addition of azomethine ylide along with sarcosine or proline (viz. sarcosine and proline series respectively) and substitution o...
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