8-Aminoquinoline amides of 3-oxo-olean-12-en-28-oic acid and 3-oxo-urs-12-en-28-oic were obtained characterized by 1H, 13C-NMR single crystal X-ray analysis. The used triterpenoic acids are oxidized forms naturally occurring oleanolic ursolic acids. Such types derivatives known for their anticancer antiviral activities. On the other hand, 8-aminoquinoline frequently transition metal complexatio...

Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function associated with increased local and systemic inflammatory markers, such as TNFα and IL-1β. Glucocorticoids are used to treat this chronic disease, however their efficacy is low and new drugs are very much required. 17-oxo-DHA is a cyclooxygenase-2-dependent, electrophilic, α,β-unsaturated keto-derivative of d...

Advanced atherosclerotic plaques demonstrate extensive DNA damage, seen in smooth muscle cells, endothelial cells, macrophages and in circulating cells, and in both nuclei and mitochondria. DNA damage includes both singleor double-stranded breaks, deleted sections of DNA, nucleotide modifications, and extrusions of DNA from the nucleus (micronuclei). Reactive oxygen species (ROS) induce a varie...

Alkyl ethoxysulphates (AES) are anionic surfactants widely used in numerous commercial and industrial applications. In spite of the high AES volume consumption a few data concerning the occurrence, fate and effects of AES in marine environments are reported in literature. The objective of this study is to evaluate the biodegradability and toxicity of AES in pristine sea water. Ultimate biodegra...

Elevated ultraviolet (UV) radiation has been demonstrated to stimulate litter decomposition. Despite years of research, it is still not fully understood whether the acceleration in litter degradation is primarily attributed to abiotic photodegradation or the combined effects of abiotic photodegradation and microbial decomposition. In this study, we used meta-analysis to synthesize photodegradat...

Expansion of a Schiff-base polypyrrolic macrocycle allows the formation of a binuclear uranyl complex with co-linear uranyl ions and a very short oxo-oxo distance.

Our own study as well as others have previously reported that hypoxia activates 15-lipoxygenase (15-LO) in the brain, causing a series of chain reactions, which exacerbates ischemic stroke. 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-oxo-eicosatetraenoic acid (15-oxo-ETE/15-KETE) are 15-LO-specific metabolites of arachidonic acid (AA). 15-HETE was found to be rapidly converted into 15-oxo-...