10.1586/14750708.4.4.441 © 2 Respiratory tract infection caused by Pseudomonas aeruginosa is one of the major causes of mortality and morbidity in cystic fibrosis patients. However, physicians treating cystic fibrosis patients are confronting the growing problem of multiple-drug resistance in P. aeruginosa. Nubiotics are a novel class of nucleotide-based drugs that have the potential to improve...

Semi-synthetic antibiotic, azithromycin (AZM) does not show significant bactericidal activity against Pseudomonas aeruginosa (P. aeruginosa). We focused on potential for AZM as a multi targeting drug P. and found combination of Polymyxin B nonapeptide (PMBN) to increase the permeability outer membrane. This is effective including multidrug-resistance clinical isolates shows 32-512-fold potentia...

The source of acquisition of Pseudomonas aeruginosa in cystic fibrosis (CF) patients remains unknown. Patient-to-patient transmission has been well documented but the role of the environment as a source of initial infection is as yet unclear. In the present study, the origin of the first P. aeruginosa isolate in CF patients was investigated by comparing the P. aeruginosa genotype(s) from newly ...

BACKGROUND AND OBJECTIVES Cystic fibrosis (CF) is an autosomal recessive genetic disease. Infections in these patients are mostly caused by three bacteria: Staphylococcus aureus, Haemophilus influenza and particularly Pseudomonas aeruginosa. Carbapenems including antibiotics are used to combat infections with Pseudomonas aeruginosa. In recent years, carbapenems resistant strains of P. aeruginos...

Pseudomonas aeruginosa is a pathogenic gram-negative organism that has the ability to cause blinding corneal infections following trauma and during contact lens wear. In this study, we investigated the directional movement and orientation of an invasive corneal isolate of P. aeruginosa in the corneal stroma during infection of ex vivo and in vivo rabbit corneas using multiphoton fluorescence an...

CONTEXT Patients with cystic fibrosis (CF) are susceptible to lower respiratory tract infections with Pseudomonas aeruginosa and typically acquire this organism in early childhood. Once P aeruginosa infection is established, eradication may be impossible, and progressive lung disease often aggravates morbidity and mortality risks. The ability to diagnose CF by genetic testing at birth makes it ...

background burn is still one of the most devastating injuries in emergency medicine while improvements in wound healing knowledge and technology have resulted into development of new dressings. this study was undertaken to evaluate the healing effect of licorice in pseudomonas aeruginosa infected burn wounds of experimental rat model. methods one hundred and twenty female sprague-dawley rats we...

Background: A most common opportunistic pathogen, Pseudomonas aeruginosa is present in both humans and animals and responsible for various nosocomial infections and healthcare settings related infections. Different virulence genes like; oprL (membrane lipoprotein L) and toxA (exotoxin A i.e. ETA) in P. aeruginosa, assist in its pathogenicity, toxicity and contribute to high antibiotic resistanc...

BACKGROUND Pseudomonas aeruginosa is a pathogen that frequently colonizes patients with cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD). Several pathogens are known to bind vitronectin to increase their virulence. Vitronectin has been shown to enhance P. aeruginosa adhesion to host epithelial cells. METHODS We screened clinical isolates from the airways of CF patients and...

BACKGROUND Putative virulence factors are responsible for the pathogenicity of UTIs caused by Pseudomonas aeruginosa (P. aeruginosa). Resistance of P. aeruginosa to commonly used antibiotics is caused by the extreme overprescription of those antibiotics. OBJECTIVES The goal of the present study was to investigate the prevalence of virulence factors and the antibiotic resistance patterns of P....