We have obtained evidence for conformational communication between ubiquinol oxidation (center P) and ubiquinone reduction (center N) sites of the yeast bc1 complex dimer by analyzing antimycin binding and heme bH reduction at center N in the presence of different center P inhibitors. When stigmatellin was occupying center P, concentration-dependent binding of antimycin occurred only to half of...

For a set P of n points in R, the Euclidean 2-center problem computes a pair of congruent disks of the minimal radius that cover P . We extend this to the (2, k)-center problem where we compute the minimal radius pair of congruent disks to cover n − k points of P . We present a randomized algorithm with O(nk log n) expected running time for the (2, k)-center problem. We also study the (p, k)-ce...