OBJECTIVES To validate the performance of the most commonly used formulas for estimation of glomerular filtration rate (GFR) against measured GFR during the index hospitalisation for ST-elevation myocardial infarction (STEMI). SETTING Single centre, methodological study. PARTICIPANTS 40 patients with percutaneous coronary intervention-treated STEMI were included between November 2011 and Fe...

Peripheral inflammation causes production of central cytokines that alter transmission at the N-methyl-D-aspartate receptor (NR). During development, NRs are important for synaptic plasticity and network connectivity. We therefore asked if neonatal inflammation would alter expression of NRs in the brain and behavioural performance in adulthood. We gave lipopolysaccharide (LPS) (100 microg/kg, i...

Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants are often prescribed to amyotrophic lateral sclerosis (ALS) patients; however, the impact of these prescriptions on ALS disease progression has not been systematically tested. To determine whether SSRIs impact disease progression, fluoxetine (Prozac, 5 or 10 mg/kg) was administered to mutant superoxide dismutase 1 (SOD1) ...

Using an antibody against tyrosine hydroxylase on newborn to 30-day kitten retinas, we have been able to follow the development of the dopaminergic amacrine cells of the cat retina by light-microscopical investigations of retinal wholemounts. The Type 1 or large Toh+ amacrine cells described by others (Oyster et al., 1985; Törk & Stone, 1979) and named A18 from a Golgi study (Kolb et al., 1981)...

OBJECTIVE To define the ability of analysis of the signal averaged P wave to identify patients with paroxysmal atrial fibrillation (AF) and establish whether differences in quantitative variables between patients and controls are due to concurrent cardiopulmonary disease, greater atrial dimension, or to unrelated changes in atrial electrophysiology. DESIGN An observational parallel group stud...

Table 1, " Percentage injury at p18 and p30 " , incorrectly appears twice. Please see the corrected Table 1 here. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

23 p23 UPDATE informs you of changes in clinical practice. This week: smoking prevalence p26 PrAcTicAl ProcEDUrEs illustrates procedures. This week: assessing consciousness p28 gUiDED lEArNiNg includes online cPD. This week: surgery and haemophilia p30 DEVEloPmENT shows how nurses are developing practice. This week: delegating consent-taking p32 rEsEArcH presents research papers. This week: pat...

23 p23 UPDATE informs you of changes in clinical practice. This week: contraception p26 PrAcTicAl PrOcEDUrEs illustrates procedures. This week: removing an indwelling catheter p28 gUiDED lEArNiNg includes online cPD. This week: law on advance decisions p30 DEVElOPmENT shows how nurses are developing practice. This week: evaluating telemedicine p32 rEsEArcH presents research papers. This week: s...

The following information is missing from the Funding section: BG is supported by NIH P30 AG10133. article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.