Leukemia, a group of hematological malignancies characterized by clonal expansion of hematopoietic cells with uncontrolled proliferation, decreased apoptosis and blocked differentiation, is one of the most notorious enemies of mankind which accounts for some 300,000 new cases and 222,000 deaths each year worldwide. Leukemia can be divided into acute or chronic, lymphoid or myeloid types, based ...

The aim of this study was to assess the impact of titanium nitride coatings on CoCr alloy metal parts in framework dentures on human palatal epithelium cytology compared to framework dentures made with the same alloy but without titanium nitride coating, and to acrylic dentures. Every prosthetic restoration introduced into the oral cavity and remaining in direct contact with the palate exhibits...

Norimitsu Inoue, M. D, Ph. D, Tomohisa Izui-Sarumaru, M. D., Yoshiko Murakami, M. D., Ph. D., Yuichi Endo, Ph. D., Jun-Ichi Nishimura, M. D., Ph. D., Ken Kurokawa, Ph. D., Maki Kuwayama, M. D., Hiroaki Shime, Ph. D., Takashi Machii, M. D., Ph. D., Yuzuru Kanakura, M. D., Ph. D., Gabrielle Meyers, M. D., Carl Wittwer, M. D., Ph. D., Zhong Chen, M. D., William Babcock, M. D., Debra Frei-Lahr, M. ...

Pseudogymnoascus destructans is the causative agent of an emerging infectious disease that threatens populations of several North American bat species. The fungal disease was first observed in 2006 and has since caused the death of nearly six million bats. The disease, commonly known as white-nose syndrome, is characterized by a cutaneous infection with P. destructans causing erosions and ulcer...

We demonstrate a new and efficient technique for modeling and simulation of spatially incoherent sources, using the Wiener chaos expansion (WCE) method. By implementing this new model, we show that a practical-size photonic structure with a spatially incoherent input source can be analyzed more than two orders of magnitude faster compared to the conventional models without sacrificing the accur...

Jackpots of mutations are the bane of transgenic mutation assays, for they can produce large mutant frequencies even in the absence of a mutagen. A jackpot is a large number of mutants that arose from a single mutation. They arise when there is a clonal expansion of a mutated cell. Jackpots as large as 1000 mutants/100 000 plaques have been observed, a mutant frequency of 1%. Such a jackpot can...

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the third leading cause of cancer mortality. Despite continuing development of new therapies, prognosis for patients with HCC remains extremely poor. In recent years, control of organ size becomes a hot topic in HCC development. The Hippo signaling pathway has been delineated and shown to be critical in controll...

Although refractory ceramic fibers have been subject to considerable toxicological evaluation, only the pooled results from two rat inhalation studies can be used to assess the occupational risk from exposure. Even in these studies, there is good evidence that the maximum tolerated dose was exceeded and that pulmonary overload occurred in the test animals. Despite these defects, we adopted a co...

A high frequency of mtDNA somatic mutation has been observed in many tumors as well as in aging tissues. In this study, we analyzed the mtDNA control region sequence variation in 3534 single normal cells and individual blasts from 18 patients with leukemia and 10 healthy donors, to address the mutation process in leukemic cells. We found significant differences in mtDNA sequence, as represented...