OBJECTIVE To examine onset of efficacy of two long-acting injectable atypical antipsychotics in markedly-to-severely ill schizophrenia subjects. METHODS This subgroup analysis included 292 subjects with baseline Clinical Global Impressions-Severity scores of markedly ill or worse from a 13-week, randomized, double-dummy noninferiority study (NCT00589914). Subjects received either: 1) paliperi...

BACKGROUND There are no previous reports of paliperidone palmitate's (PP) long term tolerability or pharmacokinetics of the highest dose in patients with schizophrenia. This study evaluates safety and tolerability, as well as pharmacokinetics, of the highest marketed dose of PP (150 mg eq. [234 mg]) in stable patients with schizophrenia over a 1-year period. METHODS In this 1-year prospective...

Objectives: Identification of early clinical markers that predict later treatment outcomes in first-episode psychosis is highly valuable. The present study was conducted to determine the best time at which to predict the late treatment response in firstepisode psychosis patients treated with paliperidone ER, factors predicting early treatment responses (at weeks 2 and 3) and the relationships b...

Objectives: Identification of early clinical markers that predict later treatment outcomes in first-episode psychosis is highly valuable. The present study was conducted to determine the best time at which to predict the late treatment response in firstepisode psychosis patients treated with paliperidone ER, factors predicting early treatment responses (at weeks 2 and 3) and the relationships b...

Long-acting injectable (LAI) antipsychotics are useful in the treatments for schizophrenic patients with poor adherence due to their maintaining feature of therapeutic plasma level without daily administrations. However, their long-lasting property can cause complicated problems such as a long-lasting side effect. We report a patient who experienced LAI-induced extrapyramidal symptoms (EPSs) fo...

BACKGROUND Over-the-counter cold medicines, which contain amantadine, are widely used in the People's Republic of China. Clinicians are familiar with the psychosis caused by long-term treatment with amantadine, especially in elderly patients; however, early-onset psychotic complications among healthy young individuals have rarely been reported. CASE PRESENTATION This article reports the case ...

Abstract Background Schizophrenia is a debilitating mental illness that affects patient’s function and quality of life. Estimates indicate lifetime prevalence 0.48%, causing up to 13.4 million years life burdened by disability. 30% these patients are deemed as having treatment-resident schizophrenia (TRS), subset which do not respond clozapine, the medication designated for TRS. Those clozapine...