The fatty acid synthetase of pigeon liver catalyzes the conversion of acetyland malonyl-coenzyme A to long chain saturated fatty acids in the presence of reduced nicotinamide adenine dinucleotide phosphate. The major product of the reaction is palmitic acid, but small amounts of other long chain fatty acids are also formed. The over-all reaction for the synthesis of palmitic acid is: 1 acetyl-C...

A possible role for an acidic subcellular compartment in biosynthesis of lung surfactant phospholipids was evaluated with granular pneumocytes in primary culture. Incubation with chloroquine (100mum) was used to perturb this compartment. With control cells, incorporation of [9,10-(3)H]palmitic acid into total lipids and into total phosphatidylcholines increased linearly with time up to 4h. Tota...

Density functional theory (DFT) analysis was carried out to explore the antioxidant properties of some flavonoids and fatty acids previously isolated from Psorospermum febrifugum spach. The geometry optimization chemical structures done following B3LYP method 6-311+G (d, p) basis set. DFT methods are fast reliable theoretical models used for evaluating reactivity electronic compounds. Reactivit...

Background: This study was carried out to determine the oil content and of fatty acids in stem, leave and seed of halophyte plant (Suaeda vermiculata ) locally called “Tahma” growing along the shorelines of the Persian Gulf in Bushehr Province. Material and Methods: The total oil and fatty acid contents of leaves, stem and root were extracted in n-hexane using Soxhlet and the fatty acid composi...

The effects of positional distribution of triacylglycerol (TAG) fatty acids to TAG structures in chylomicrons and VLDL, and to postprandial lipemia, were studied in 10 healthy premenopausal women using a 6-h oral fat load test and a randomized, double-blind cross-over design. Molecular level information of TAG regioisomerism was obtained with a tandem mass spectrometric method. The positional d...

In a previous communication (1) it was reported that an L-a-hydroxy aliphatic acid was required as a cofactor for the limited oxidation of palmitic acid by a soluble cytoplasmic protein fract,ion obtained by precipitation with ammonium sulfate from extracts of cotyledons of germinating peanuts. This fraction was designated supernatant enzyme. No additional cofactors were required, and activity ...

Brassica napus leaves developed at low temperature display rapid in situ desaturation of monogalactosyldiacylglycerol (MGDG) fatty acids leading to the production of hexadecatrienoic/linolenic acid. This was shown by radioactivity-tracer experiments to occur via a sequence of desaturations proceeding from the initially synthesized palmitic/oleic acid molecular species to palmitic/linoleic acid,...

The hypothesis that myristic acid (C14:0) has a stronger cholesterol-increasing potential than does palmitic acid is based on very few experimental observations. A randomized, strictly controlled dietary study was therefore designed to investigate the effect of a synthetic fat that was high in myristic acid, and palm oil, which is high in palmitic acid, on lipoproteins and hemostatic variables....

Elevated circulating levels of NEFAs (non-esterified fatty acids) are associated with states of insulin resistance and increased risk of vascular disease. Previous animal and human studies have demonstrated NEFA-induced endothelial dysfunction of large conduit arteries, reversible by the antioxidant ascorbic acid. We therefore investigated the effect of NEFAs on carbachol-induced endothelium-de...