OBJECTIVES We explored the feasibility, difficulty, and indications for laparoscopic pancreaticoduodenectomy. METHODS Since November 11, 2002, we have successfully completed 5 laparoscopic pancreaticoduodenectomies. Patients included 4 males and 1 female, average age 43 years. Three patients had duodenal papillary cancer, one had cancer of the head of the pancreas, and one had pancreatic mixe...

Ductal adenocarcinoma is the most common primary malignant disease of the pancreas and periampullary region. It accounts for more than 75% of all nonendocrine tumors arising in this region, which includes the pancreas, the ampulla of Vater, the distal common bile duct, and the perivaterian duodenum. Pancreatic adenocarcinoma is the most common of the periampullary neoplasms. In the United State...

We studied reactivity of cytokeratins (CK) 7, 17, and 20 in 64 pancreaticobiliary adenocarcinomas to examine the effect of different cut-point thresholds on “positive” results, compare ampulla of Vater and pancreas adenocarcinomas, and provide additional experience with CK17 reactivity. Almost all neoplasms had extensive CK7 reactivity. The number of CK20positive cases decreased from 29 (45%; a...

Intraductal papillary mucinous neoplasms (IPMNs) are characterized by the papillary proliferation of atypical mucinous epithelial cells in the pancreatic ductal system. There are two recurrence patterns following resection of IPMNs: Metachronous multifocal occurrence of IPMNs, and distinct pancreatic ductal adenocarcinoma (PDAC) in the remnant pancreas. Several recent studies investigated the d...

Primary squamous cell carcinoma of the pancreas (SCCP) is a rare neoplasm, given a lack of naturally occurring squamous cells within the pancreas, accounting for only 0.2% of all pancreatic cancers. The etiology is unknown. Symptomatology is non-specific and similar to other pancreatic neoplasms. No non-invasive testing can adequately rule in SCCP, and workup should proceed similarly to any pan...

A 64-year-old man was transferred to our division with a suspicion of gastric cancer. Computed tomography showed widespread irregular thickening of the stomach walls close to the liver and pancreas. Gastrointestinal fiberscopy showed a type 5 tumor in the upper to lower stomach, histologically diagnosed as tubular adenocarcinoma. Gastric cancer with hepatic and pancreatic invasion was diagnosed...

Risk factors for anastomotic leaks of pancreaticojejunostomy have been well described. We present a technique using indocyanine green dye (ICG) and a near-infrared (NIR) capable laparoscope to assess blood supply to the transected margin of the pancreas before pancreaticojejunal anastomosis. A 39-year-old female patient underwent a laparoscopic-assisted pancreaticoduodenectomy (Whipple's proced...

BACKGROUND The pancreas is a rare but occasionally favored target for metastasis. Metastatic lesions in the pancreas have been described for various primary cancers, such as carcinomas of the lung, the breast, renal cell carcinoma and sarcomas. CASE PRESENTATION We report the case of a 60-year old female with a mass in the pancreatic head four years after partial gastrectomy for gastric adeno...

Postoperative early recurrence is a frequently observed serious problem, even after macroscopically curative resection in patients with pancreatic adenocarcinoma. The effect of adjuvant chemotherapy may be limited these patients. A dismal prognosis indicates the limitation upfront surgery and strategy, alternative such as neoadjuvant suitable for them. In this study, we retrospectively investig...

Contrasting with improved survival for most other gastrointestinal cancers, the 5-year survival of patients with ductal adenocarcinoma of the pancreas remains low at a dismal 4%. In 2000, an estimated 28,300 patients were diagnosed with pancreatic cancer in the United States These patients can expect to benefit from some progress in management. Minimally invasive procedures such as helical comp...