Pancreatic malformations usually represent a surgical challenge, however, depending on the anatomical location even complex procedures such as pancreatic head resection may be facilitated. In a 78-year-old-woman the unique observation of a missing pancreatic isthmus was made during pylorus-preserving pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. Resection of the pancreatic head ...

Background. Both IL-9 and miR-200a are involved in the pathogenesis of cancers; however, the role of IL-9 in pancreatic cancer and the possible underlying mechanisms remain unknown. The aim of this study was to investigate the effect of IL-9 on pancreatic cancer cells and its interaction with miR-200a. Methods. Pancreatic cancer cells (PANC-1 and AsPC-1) were treated with IL-9 and the expressio...

CONTEXT The role of protein components of pancreatic secretions has been controversial in pancreatic stone formation. OBJECTIVE To study the lithogenic role of pancreatic stone protein and lactoferrin in stone formation in chronic pancreatitis. PATIENTS Pancreatic stones were collected from 13 patients with alcoholic (n=6) and nonalcoholic (n=7) chronic calcified pancreatitis. MAIN OUTCOM...

PURPOSE Cancer associated stromal fibroblasts (CAFs) undergo transcriptional and phenotypic changes that contribute to tumor progression, but the mechanisms responsible for these changes are not well understood. Aberrant DNA methylation is an important cause of transcriptional alterations in cancer cells but it is not known how important DNA methylation alterations are to CAF behavior. EXPERI...

An experimental study on the changes in the pancreatic exocrine functions before and after pancreaticoduodenectomy (PD) for the treatment of periampullary carcinoma was performed. Pancreatic insufficiency models with pancreatic duct stenosis was prepared with dogs by giving them complete ligation of the minor pancreatic duct and intubation into the major pancreatic duct. After 3 months of pancr...

W pancreatic injuries are relatively uncommon, the morbidity and mortality associated with such injuries are high. Of all pancreatic injuries, most result from penetrating rather than blunt trauma. It is estimated that 6% of abdominal gunshot wounds and 2% of abdominal stab wounds result in a pancreatic injury. The mortality associated with pancreatic injuries ranges from 20% to 45%, while the ...

Pancreatic pseudocyst is a complication of pancreatic trauma. We describe improved nonoperative treatment of patient with posttraumatic pancreatic pseudocyst with somatostatin analogue. A 9-year-old girl was admitted to our hospital after blunt abdominal trauma with handlebar. Three weeks after abdominal trauma, pancreatic pseudocyst developed. Nonoperative treatment of posttraumatic pancreatic...

Gross calcification of the pancreatic head in adolescence is a rare condition which raises the possibility of hereditary chronic pancreatitis (HCP) even in the absence of a family history [1]. HCP leads to premature autocatalytic activation of trypsinogen to trypsin. This results in imbalance between intra-pancreatic proteases and their inhibitors, progressing to exocrine and endocrine pancreat...

PURPOSE Hypermethylation of CpG islands in the promoters of selected genes is a common feature of neoplasia. Aberrant methylation of cyclin D2 has been observed in several cancers. We investigated the methylation of cyclin D2 in aging and pancreatic neoplastic development, and the utility of cyclin D2 methylation as a marker of pancreatic adenocarcinoma. EXPERIMENTAL DESIGN Methylation-specif...

PURPOSE Effective new markers of pancreatic carcinoma are urgently needed. In a previous analysis of gene expression in pancreatic adenocarcinoma using serial analysis of gene expression (SAGE), we found that the tag for the mesothelin mRNA transcript was present in seven of eight SAGE libraries derived from pancreatic carcinomas but not in the two SAGE libraries derived from normal pancreatic ...