BACKGROUND The pathology of non-alcoholic chronic pancreatitis has not yet been sufficiently studied. AIMS To identify the major changes of pancreatic tissue in patients surgically treated for non-alcoholic chronic pancreatitis. PATIENTS Pancreatectomy specimens from 12 patients with non-alcoholic chronic pancreatitis, including four patients with autoimmune or related diseases (Sjögren's s...

Serum feline trypsinogen-like immunoreactivity (fTLI) concentrations and abdominal ultrasound have facilitated the noninvasive diagnosis of pancreatitis in cats, but low sensitivities (33% and 20-35%, respectively) have been reported. A radioimmunoassay has been validated to measure feline pancreatic lipase immunoreactivity (fPLI), but the assay's sensitivity and specificity have not been estab...

OBJECTIVE To assess the sensitivity and specificity of the serum carboxypeptidase B activation peptide in diagnosing and determining the severity of acute pancreatitis. PATIENTS Twenty consecutive patients with acute pancreatitis were studied on admission to the Emergency Room: 11 patients had mild pancreatitis, and 9 patients, severe pancreatitis. Twenty consecutive patients with non-pancrea...

Chronic pancreatitis is characterized by irreversible damage to the pancreas that eventually leads to pain and/or exocrine and endocrine insufficiency. It is a major health problem worldwide and is associated with considerable morbidity. Alcohol is the most common cause of chronic pancreatitis worldwide. Still in a large proportion of patients with chronic pancreatitis no etiology can be identi...

CONTEXT Ischemia is an established cause of acute pancreatitis; however, acute pancreatitis has never been reported after cardiac arrest. CASE REPORT We report a case of acute pancreatitis following cardiac arrest with prolonged cardiopulmonary resuscitation in a 58-year-old man, the mechanism of which is likely to be ischemic. The patient developed severe ischemic encephalopathy, leading to ...

Fifty one patients (median age 78, range 54-92) who had endoscopic sphincterotomy for gall stone pancreatitis without planned cholecystectomy were followed up to assess the effectiveness of this treatment in preventing further acute pancreatitis. In 48 patients sphincterotomy was technically successful and none had further acute pancreatitis after a mean follow up of 26.9 months. In three patie...

CONTEXT Autoimmune pancreatitis is a relatively rare, yet well described cause of chronic pancreatitis. Extrapancreatic findings are now recognized as important manifestations of this entity and viewed as part of a larger disease process tentatively named "IgG4-associated sclerotic disease". CASE REPORT We herein report a case of autoimmune pancreatitis with histopathologically proven gastric...

Hereditary chronic pancreatitis associated with a mutation in the serine protease inhibitor, Kazal Type-1 (SPINK-1 gene) is extremely rare. The SPINK1 mutation results in trypsinogen activation which predisposes to chronic pancreatitis predominately when combined with CFTR gene mutations. It presents as either chronic or recurrent acute pancreatitis. Symptom control and management of complicati...

CONTEXT Pancreatic stellate cell (PSC) is known to be the source of fibrosis in pancreatic pathology of various etiologies. However, there is no published data on activation of PSCs in tropical calcific pancreatitis. OBJECTIVES The present study was undertaken to estimate the proportion of activated stellate cells, in a semi-quantitative manner, in normal pancreas and pancreatic fibrosis due ...

Few data are present in the literature on the relationship between atorvastatin use and acute pancreatitis. The aim of this study was to explore this issue in Taiwan. Using representative claims data established from the Taiwan National Health Insurance Program, this case-control study consisted of 5810 cases aged 20 to 84 years with a first-time diagnosis of acute pancreatitis during the perio...