IN a previous communication [Macrae et at. 1939] we described the preparation from liver extracts of highly potent concentrates of a nutritional factor for rats to which we applied the name "liver ifitrate factor" [cf. Edgar et al. 1938].; At that time we drew attention to the similarity in properties between this factor and pantothenic acid [Williams et al. 1938; 1939] and discussed the possib...

During the past 6 years, experiments have been reported from this laboratory on swine in which deficiencies in vitamins of the B complex have been produced. Of particular interest have been the studies on the relationship of vitamin deficiency to the integrity of nervous tissues. I t was first shown that degeneration of the peripheral nerves, dorsal root ganglion cells, and posterior columns of...

1. The content of total pantothenic acid (PaA) in two foodstuffs of microbial origin was measured by standard microbiological and chick biological assays. 2. Substantially and consistently higher values were found by the chick assay than by the microbiological determination, indicating that PaA-containing compounds were present that were not utilized by the test micro-organisms but were availab...

may cause peripheral nerve dysfunction suggests that lack of these or other B-complex vitamins may also contribute to neuropathy in the malnourished alcoholic. The present investigation was therefore undertaken to evaluate further the role of aneurin and other B-complex vitamins in the development of this condition. The study consisted of (a) determining circulating levels of aneurin, riboflavi...