A simple, rapid, reproducible, accurate and precise Reverse Phase HPLC method was developed for the quantitative simultaneous estimation of Drotaverine hydrochloride and Paracetamol in combined tablet dosage form. Drotaverine hydrochloride is an analog of papaver and is used mainly as an antispasmodic, smooth muscle relaxant. Paracetamol has analgesic and antipyretic activity. The chromatograph...

BACKGROUND In Ireland, 30% of non-fatal overdoses involve paracetamol. AIMS To determine how and where patients obtained paracetamol, to assess awareness of toxicity and examine the relationship between dose and suicidal intent. METHODS A prospective study of patients admitted following a paracetamol overdose recording their reasons for using paracetamol, their knowledge of its toxicity and...

Harm from medications can arise from unintended consequences as well as medication error. Paracetamol is a frequently used analgesic and anti-pyretic drug which is widely available without a prescription. Medical professionals have concluded that long-term use, or large doses of Paracetamol can cause harm to the body or even death, although many mistakenly believe it to be completely harmless. ...

backround: we aimed to evaluate analgesic efficacy, opioid-sparing, and opioid-related adverse effects of intravenous paracetamol and intravenous dexketoprofen trometamol in combination with iv morphine after total abdominal hysterectomy. materials and methods: sixty american society of anesthesiologist physical status classification i-ii patients scheduled for total abdominal hysterectomy were...

A spectrophotometric flow injection method for the determination of paracetamol in pharmaceutical formulations is proposed. The procedure was based on the oxidation of paracetamol by sodium hypochloride and the determination of the excess of this oxidant using o-tolidine dichloride as chromogenic reagent at 430 nm. The analytical curve was linear in the paracetamol concentration range from 8.50...

New regulations for the control of paracetamol come into force in October 2001. These are greatly welcomed and should lead to a reduction in paracetamol poisoning. Existing conditions for the sale and supply of paracetamol (Irish Medicines Board (IMB), 1997), which have no statutory basis, state that non-pharmacy outlets should only sell emergency supplies of paracetamol in a maximum pack size ...

conclusions according to the results of the current study, postoperative analgesia in children was improved in the ketamine group. therefore, for better management of posttonsillectomy pain, low-dose ketamine administration with paracetamol is recommended. results there was no significant difference between the two groups considering demographic data (age, sex distribution, weight and height). ...

AIM To evaluate and compare the analgesic activity of fixed dose combinations (FDC) of Paracetamol with Diclofenac sodium and Paracetamol with Tramadol on different human pain models in healthy human volunteers. MATERIALS AND METHODS A randomized double blind crossover study was carried out in 30 healthy human volunteers using three pain models; cold-water stress test, radiant heat method, an...

OBJECTIVE To investigate the effect of regular paracetamol on bronchial hyper-responsiveness (BHR) and asthma control in adult asthma. SETTING Single research-based outpatient clinic. PARTICIPANTS 94 adults with mild-to-moderate asthma received randomised treatment; 85 completed the study. Key inclusion criteria were age 18-65 years, forced expiratory volume in 1 s (FEV1) >70% predicted, pr...