north-western iran comprises diverse geographical landscapes, including pastures of piedmonts, mountains, and well-watered plains. the present chronology of this region, nevertheless, is based exclusively on data collected from sites around the urmia lake, other regions being almost totally ignored. during the late bronze age (hereafter lba) a new way of life took shape in the mountainous regio...

Abstract. One of modern global optimization algorithms is method Strongin and Piyavskii modified by Sergeev Kvasov diagonal approach. In recent paper we propose an extension this approach to continuous multivariable functions defined on the multidimensional parallelepiped. It known that applies only a Lipschitz function though it effectively extends one-dimensional algorithm case. So authors mo...

We propose an approach to the description of orientational phase transitions that utilizes the specific features of orientational energy and entropy. The approach is applied to building a model for nematic phases in materials with nonpolar parallelepiped-type molecules with symmetry D(2h). The model operates with complex order parameters, generalizes the Landau-de Gennes theory, and predicts th...

Thyrotoxicosis due to Graves disease is a relatively common endocrine disorder. The occurrence of a prolactinoma with co-secretion of growth hormone (GH) is on the other hand, rare. We report the rare co-existence of Graves' disease in a patient with macroprolactinoma and GH hypersecretion and describe the successful response to medical therapy with dopamine agonist and antithyroid therapy. We ...

Management of Graves' orbitopathy remains an important therapeutic challenge. Current therapeutic modalities are unsatisfactory in about one third of patients. Rituximab is a monoclonal antibody against CD20 antigen that is expressed in mature and immature B cells. Early experience with rituximab suggests that it is a promising alternative therapy for Graves' orbitopathy. Here we report a case ...

Sinusoidal horizontal vibrations have been applied to a parallelepiped containing rounded sand grains. To model the granular medium behavior, a commercial software based on Molecular Dynamics has been used. The influence on the rheologic behavior of many process parameters, such as the dimensionless acceleration and the frequency has been studied. The velocity, density, pressure and mass flow f...

Type 1 diabetes mellitus (DM) and Graves' disease are autoimmune diseases, and a number of genetic factors, including HLA and CTLA-4 genes, have been reported to contribute to their etiology. The gene responsible for autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED) has been cloned and named the autoimmune regulator-1 (AIRE-1) gene. AIRE-1 protein is thought to be a trans...

The association between vitamin D levels and Graves' disease is not well studied. This update review aims to further analyze the relationship in order to provide an actual view of estimating the risk. We searched for the publications on vitamin D and Graves' disease in English or Chinese on PubMed, EMBASE, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. T...

In order to determine the frequency of thyroxine (T4) toxicosis and study the possibility of usefulness for differentiation between thyrotoxic Graves' disease and destructioninduced thyrotoxicosis, the serum concentrations of T4, triiodothyronine(T3), reverse T3 (rT3), and T4-binding globulin (TBG) and the values of T3-uptake and radioactive iodine uptake (RAIU) were measured, and free, T4 inde...