The aim of the present study was to evaluate the pesticide residues in human blood samples of volunteers related to Hyderabad and Mirpurkhas districts, Pakistan. The volunteers of both districts were divided into four groups on the basis of their exposure period to pesticides i.e. Group A—5 to 9 years, Group B—10 to 14 years, Group C—15 to19 years and Group D—above 20 years. Out of total 188 vo...

BACKGROUND The majority of rural population in Iran depends on groundwater resources for drinking purposes. In recent years, pesticide contamination of limited water resources has become a serious challenge worldwide. This study quantified the pesticides residue in rural groundwater resources in the northwest of Iran. METHODS A total of 78 groundwater samples were collected in June and Sep-te...

*Abu-Qare AW, Abou-Donia MB. 2001. Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. Agency for Toxic Substances and Disease Registry. 1989. Decision guide for identifying substance-specific data needs related to toxicological profiles; Notice. The effects o...

Organophosphorus pesticides (OPs) are a public health concern due to their worldwide use and documented human exposures. Phosphorothioate OPs are metabolized by cytochrome P450s (P450s) through either a dearylation reaction to form an inactive metabolite, or through a desulfuration reaction to form an active oxon metabolite, which is a potent cholinesterase inhibitor. This study investigated th...

Pesticide consumption causes, pollution of groundwater, surface water and soil.Its use is increasing at an alarming rate, for increasingthe agricultural yield. Their extensive use exerts profound and deleterious effects on wildlife populations and humans. Methyl parathion(MP) is one such pesticide which is widely used throughout the world to protect the crops from chewing and sucking insects su...

Protein thermostability can be increased by some glycine to proline mutations in a target protein. However, not all glycine to proline mutations can improve protein thermostability, and this method is suitable only at carefully selected mutation sites that can accommodate structural stabilization. In this study, homology modeling and molecular dynamics simulations were used to select appropriat...