The pathogeneses of parathyroid disease in patients with uremia and nonfamilial primary parathyroid hyperplasia are poorly understood. Because of multigland involvement, it has been assumed that these common diseases predominantly involve polyclonal (non-neoplastic) cellular proliferations, but an overall assessment of their clonality has not been done. We examined the clonality of these hyperp...

Parathyroid carcinoma is a rare endocrine neoplasm that accounts for <1% of cases primary hyperparathyroidism. The management parathyroid challenge due to the high rate local recurrence tumour. We report case middle-aged north Indian woman who presented with recurrent hyperparathyroidism carcinoma. She palpable hard neck mass and underwent radical dissection six times. At time writing this r...

INTRODUCTION It is essential to know the thyroid gland morphology and its anatomical relations in the anterior compartment of the neck in order to minimize the rate of thyroid surgery morbidity, especially the lesion of parathyroid glands and laryngeal nerves. The aim of this study was the identification of parathyroid glands in cadaver parts and their histological confirmation. MATERIAL AND ...

Primary hyperparathyroidism (PHPT) is a common endocrinopathy, frequently caused by a parathyroid adenoma, rarely by a parathyroid carcinoma that lacks effective oncological treatment. As the majority of cases are present in postmenopausal women, oestrogen signalling has been implicated in the tumourigenesis. Oestrogen receptor beta 1 (ERB1) and ERB2 have been recently identified in parathyroid...

Giant parathyroid adenomas are uncommon. Its clinical management is challenging. Our study’s goal to share our experience with pre-operative localization of while emphasizing the importance intraoperative hormone (IOPTH) assays in such situations. Here, we present case a 46-year-old woman who was diagnosed adenoma. The aspects, management, and surgical procedure have all been examined. Parathyr...

Parathyroid carcinoma is a rare disease that needs an additional diagnostic tool and wide therapeutic options. The genomics proteomics approach may help to find the tools improve prognosis of by early detection metastatic control. findings from were mainly CDC73, PRUNE2, CCND1, genes related PI3K/AKT/mTOR Wnt pathways. CCND1 closely each other, PRUNE2 are expression levels parafibromin protein,...

Abstract Parathyroid scintigraphy is an imaging technique that uses gamma-emitting radionuclide to locate hyperfunctioning parathyroid glands in patients with hyperparathyroidism. It valuable for preoperative assessment before parathyroidectomy, which a curative surgery most cases of primary hyperparathyroidism and some secondary There are several different techniques scintigraphy. In general, ...

Background: Parathyroid hormone is known as one of the main uremic toxicants, which, if amount increases in plasma, will affect motor conduction patients with chronic kidney disease. This study aims to determine relationship between levels neuropathy disease.
 Methods: was an analytic observational a cross-sectional approach, where many 42 subjects participated this study. Data analysis pe...

Four monoclonal anti-parathyroid antibodies were generated after immunization of mice with intact cells from human parathyroid tissue. All four monoclonal antibodies reacted in immunohistochemistry with structures present on parathyroid epithelial cells and proximal-tubule cells of the kidney but were unreactive with all other human tissues investigated. Immunofluorescence microscopy on suspend...

The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aort...