Osteoporosis is a disease characterized by losing bone tissue, resulting in increased fragility and an risk of fractures. Parathyroid hormone (PTH) plays essential role the development osteoporosis. High levels PTH for prolonged periods lead to decrease density. However, intermittent administration effective treatment osteoporosis, suggesting that careful dosing can have therapeutic benefit

The review describes the problem of studying progressive changes hormones concentrations (parathyroid hormone, insulin, somatotropin, prolactin) in patients with chronic renal failure on pre-dialysis and dialysis stages. pathogenetic relationships between kidney function deterioration hormone as well their biological effects were evaluated. Parathyroid is considered an uraemic toxin, since its ...

In a woman with hereditary fructose intolerance and intact parathyroid function, the experimental administration of fructose at different dosage schedules invariably induced the dose-dependent, complex dysfunction of the proximal renal tubule now recognized as characteristic. But in a woman with hereditary fructose intolerance and hypoparathyroidism given similar amounts of fructose, the experi...

HELLMAN, DOROTHEA E., WILLIAM Y. W. Au, AND FREDERIC C. BARTTER. Evidence for a direct effect of parathyroid hormone on urinary acidijcation. Am. J. Physiol. 2og(3) : 643-650. Ig65.The effects of intravenously administered parathyroid extract and of a purified parathyroid hormone on urinary acidification and on solute excretion were measured in six thyroparathyroidectomized dogs, in three norma...

Considerable attention has been given in the past to the action of parathyroid hormone in promoting calcium mobilization and phosphate diuresis (1). In an effort to gain some insight into the mechanism of action of parathyroid hormone at the molecular level, studies on its biochemical action at the subcellular level have been pursued in this laboratory. It has been shown that parathyroid hormon...

In rats, gastrointestinal aluminum absorption and tissue distribution were altered by parathyroid hormone; the resultant tissue concentrations were similar to those observed in dialysis patients with a fatal encephalopathy. In dialysis patients, serum aluminum and endogenous parathyroid hormone concentrations are significantly correlated. These data suggest that aluminum toxicity in dialysis pa...

Most investigations on the metabolic action of parathyroid hormone have suffered from an important limitation; i.e., the heterogeneity of the cell population of the tissue under study. However , as it has been reported that parathyroid hormone also affects many tissues (1-4), it is

Hyperparathyroidism represents as a novel feature of primary aldosteronism (PA). Its occurrence in patients with the surgically correctable aldosterone-producing adenoma (APA) and not in those with bilateral adrenal hyperplasia suggested that the measurement of parathyroid hormone could help in differentiating between these subtypes of PA. To test this hypothesis we measured the plasma levels o...

Impaction allograft is an established method of securing initial stability of an implant in arthroplasty. Subsequent bone integration can be prolonged, and the volume of allograft may not be maintained. Intermittent administration of parathyroid hormone has an anabolic effect on bone and may therefore improve integration of an implant. Using a canine implant model we tested the hypothesis that ...

Hyperparathyroidism represents as a novel feature of primary aldosteronism (PA). Its occurrence in patients with the surgically correctable aldosterone-producing adenoma (APA) and not in those with bilateral adrenal hyperplasia suggested that the measurement of parathyroid hormone could help in differentiating between these subtypes of PA. To test this hypothesis we measured the plasma levels o...