introduction: the purpose of this study is to assess the integrated role of scintigraphy by tc99m mibi in diagnosis of parathyroid adenoma and its impacts on the myocardium, and to evaluate whether myocardium perfusion gated spect study could be a complementary routine workup for patient with positive parathyroid adenoma on tc99m mibi parathyroid scan. methods: rest myocardium perfusion gated s...

BACKGROUND Primary hyperparathyroidism is caused by the excessive growth of parathormone secretion, its consequence being hypercalcemia. The parathyroid adenoma is responsible for over half of primary hyperparathyroidism cases. The mandibular tumor can be the initial sign in the case of primary hyperparathyroidism. CASE PRESENTATION We present the case of a 33 year old patient with history of...

Brown tumors are considered one of the most pathognomonic skeletal changes that accompany primary hyperparathyroidism (PHPT). It results from excessive secretion of parathyroid hormone (parathormone or PTH). The mandible is the most involved facial bone by brown tumor. Ectopic located parathyroid adenoma is uncommon, and thus, its diagnosis and management can sometimes be challenging. Difficult...

Subcutaneous Parathyroid Hormone in ADH1 In this letter, the investigators report that continuous subcutaneous infusion of parathyroid hormone (1-34) six patients who were between ages 5 ...

BACKGROUND Technetium-99m sestamibi scintigraphy has become one of the most popular techniques for localization of the parathyroid gland after failure of primary neck exploration. OBJECTIVE To examine the efficacy of sestamibi with the hand-held gamma ray detecting probe for the identification of parathyroid adenomas during revision parathyroidectomy. METHODS We reviewed six cases of probe-...

OBJECTIVE Hypercalcaemia is an important cause of increased morbidity and mortality in patients with parathyroid carcinoma. Surgical resection is the mainstay of treatment but, equally, managing hypercalcaemia is of paramount importance. At present, few therapies have been shown to be effective in the most severe cases. This report describes the efficacy of denosumab in a patient with parathyro...

Hypercalcemia with concomitant elevation of serum parathyroid hormone (PTH) and PTH-related protein (PTHrP) levels was found in a patient with advanced gastric carcinoma and multiple liver metastases. The most common features are hypercalcemia associated with hypersecretion of PTHrP and physiological suppression of PTH secretion in the syndrome of humoral hypercalcemia of malignancy (HHM). Alth...

Secondary hyperparathyroidism is one of the most important abnormalities in chronic kidney disease-mineral and bone disorder (CKD-MBD). Despite the recent development of therapeutic modalities including new phosphate binders, new vitamin D analogues and cinacalcet, many patients with very severe hyperparathyroidism still remain uncontrollable. Several studies have demonstrated that such refract...

Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the (11)C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using t...

Introduction: The purpose of this study is to assess the integrated role of scintigraphy by Tc99m MIBI in diagnosis of parathyroid adenoma and its impacts on the myocardium, and to evaluate whether myocardium perfusion gated SPECT study could be a complementary routine workup for patient with positive parathyroid adenoma on Tc99m MIBI parathyroid scan. Methods: Rest myocardium perfusion gated ...