We report the cutaneous side effects of Iressa (ZD1839), a new anti-cancer agent that acts by inhibiting epidermal growth factor receptor signal transduction. The most common cutaneous adverse effect was the development of an acneiform eruption on the face, anterior trunk and back (39%). The second most common side effect was xerosis or desquamation of the face, body or distal parts of the fing...

INTRODUCTION Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the charac...

The ornamental horticulture industry has long been significant in its vast economic contributions to the US agricultural sector, with Florida ranking second nursery and greenhouse plant sales. A small proportion of introduced plants eventually escape cultivation become invasive, leaving fragile ecosystems at risk. In response, a series propagation production research studies have conducted over...

Objective: Scabies is one of the diseases that can be minimized with preventive health measures. Accurate diagnosis scabies important for both patient and public health. Diagnosis in children challenging, since clinical features may differ from those adults. The aim present study was to investigate demographic characteristics patients childhood. Material Methods : aged 0-18 years, who were diag...

There have become available, recently both in Paresthesia this country and abroad, “sculptured” artificial nails A long recognized, unique feature of allergic contact based on acrylates that are “photobonded. " The dermatitis caused by the acrylic monomer is a bonding is said to be similar to urestorative dental distressing paresthesia of the fingertips on the form of a bonding” commonly used b...

This phase I trial was conducted to determine the maximum tolerated dose (MTD) and recommended dose of afatinib for phase II trial in elderly patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The study used a standard 3 + 3 dose escalation design. Patients aged 75 years or older with advanced NSCLC harboring EGFR mutations wer...

To cite: Doleschal B, Petzer A, Aichberger KJ. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2016-218980 DESCRIPTION Awoman aged 69 years treated with adjuvant docetaxel every 3 weeks for luminal-B breast cancer, presented with nail dystrophies. On clinical examination, nested nail plates (figure 1A, C) divided by deep transverse sulci (figure 1B, D) on all 10 ...

PURPOSE Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling pathway is constitutively activated in melanoma. AZD6244 blocks MEK1/2, inhibiting ERK phosphorylation. We focus on associated cutaneous toxicity and we attempt to understand the underlying pathophysiology and design treatment strategies. EXPERIMENTAL DESIGN Dermatologic conditions of ...