نتایج جستجو برای: participatory irrigation management pim
تعداد نتایج: 905904 فیلتر نتایج به سال:
Personal information management (PIM) is a basic human-computer activity in which the same user saves and organizes the information as well as retrieves it later. Because hundreds of millions of users save and retrieve their personal information many times a day, even the smallest improvement in the human-computer interface can generate a significant improvement in their overall productivity an...
Abstract Objectives We aimed to evaluate the impact of potentially inappropriate medications prescribed prior hospitalization (PIM-ph) on mortality Methods included 318 patients, aged ≥65 who sought emergency care and were hospitalized for any clinical reasons. Information patients' social indicators was obtained via structured interviews conducted 24 48 hours after hospitalization. All used by...
The Pim kinases are weak oncogenes. However, when co-expressed with a strong oncogene, such as c-Myc, Pim kinases potentiate the oncogenic effect resulting in an acceleration of tumorigenesis. In this study we show that the least studied Pim kinase, Pim-3, is encoded by a gene directly regulated by c-Myc via binding to one of the conserved E-boxes within the Pim3 gene. Accordingly, lymphomas ar...
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. PIM kinases act in downstream effector functions as inhibitors of apoptosis and as positive regulators of G1-S phase progression through the cell cycle. PIM kinases are u...
The paper discusses different approaches of watershed management programs implemented in South Asian countries, with special reference to Nepal based on existing literature and field experiences. Watershed degradation, particularly in mountainous areas, is critical problem in South Asian countries. A participatory approach has been adopted in watershed and natural resource management during the...
In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmiss...
OBJECTIVES To describe the prevalence and determinants of potentially inappropriate medication (PIM) use and association with hospitalizations in an elderly managed care population in Switzerland. METHODS Using health care claims data of four health insurers for a sample of managed care patients 65 years of age and older to compare persons on PIM with persons not on PIM. Beers' 2012 and PRISC...
The Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative phosphorylation. Drugs targeting the Pim protein kinases are being tested in phase I/II clinical trials for the treatment of hematopoietic malignancies. The goal of these studies was to identify Pim substrate(...
Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we analyzed the mode of action of PIM anti-inflammatory effects. Synthetic PIM(1) isomer and PIM(2) mimetic potently inhibit TNF and IL-12 p40 expression induced by TLR2 or TLR4 ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید