Architectural proteins mediate interactions between distant sequences in the genome. Two well-characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb-containing sites to facilitate silencing. The nature of which sequences interact genome-wide appears to be determined by the orientation of the architectural prot...

We show that the mechanism by which chromatin displaying higher-order structure is usually isolated from nuclei involves a transition to an extended nucleosomal arrangement. After being released from nuclei, chromatin must refold in order to produce the typical chromatin fibers observed in solution. For starfish sperm chromatin with a long nucleosome repeat (222 bp), isolated fibers are signifi...

PURPOSE To develop perimetric stimuli for which sensitivities are more resistant to reduced retinal illumination than current clinical perimeters. METHODS Fifty-four people free of eye disease were dilated and tested monocularly. For each test, retinal illumination was attenuated with neutral density (ND) filters, and a standard adaptation model was fit to derive mean and SEM for the adaptati...

Tras un complicado año generado por la covid19, donde el arte ha servido mucho más que como mero entretenimiento, ARTSEDUCA desea poner en valor a todos los artistas, de ámbitos. Gracias ellos, su predisposición y disposición siempre para mejorar sociedad, luchando conseguir lugar mejora tomar posición educación una necesidad derecho. En este número volvemos mostrar importantes trabajos vincula...