Cardiovascular diseases are a major health concern all over the world and, especially, heart failure has gained more importance in the recent years. Improving diagnosis and therapy is therefore critical and among the several resources at our disposal, implantable devices is expected to have a better rate of success. This paper is focused on two topics: (i) our views of the main challenges to fa...

The multi-agent path finding (MAPF) problem is a generalization of the single-agent path finding problem for k > 1 agents. It consists of a graph and a number of agents. For each agent, a unique start state and a unique goal state are given, and the task is to find paths for all agents from their start states to their goal states, under the constraint that agents cannot collide during their mov...

The goal of the OptIPuter project is to tightly couple research applications with dynamically allocated paths. Since OptIPuter is a multi-disciplinary project, the paths through the network often span multiple network domains, and the applications are challenged to find valid network connections through these

In this paper we present eCoology, an AR edutainment application for children in which emotional and social aspects are taking into consideration to improve flow or optimal experience. Particularly, we investigate the introduction of emotional agents that react and move within the AR environment according to their emotional state. We propose a model for emotional agents and a path finding mecha...

This paper describes a technique for finding paths through a two dimensional continuous space using a genetic algorithm. While A* currently dominates the field of pathfinding, it requires that the space be discretized. For spaces which are not easily discretized, or in which a fixed grid size is not permissible, a pathfinding algorithm which does not require discretization is necessary. In addi...

huckebein encodes a putative zinc finger protein expressed in a subset of Drosophila CNS precursors, including the NB 4-2/GMC 4-2a/RP2 cell lineage. In huckebein mutant embryos, GMC 4-2a does not express the cell fate marker EVEN-SKIPPED; conversely, huckebein overexpression produces a duplicate EVEN-SKIPPED-positive GMC 4-2a. We use Dil to trace the entire NB 4-2 lineage in wild-type and hucke...

The corpus callosum is the most prominent commissural connection between the cortical hemispheres, and numerous neurodevelopmental disorders are associated with callosal agenesis. By using mice either with meningeal overgrowth or selective loss of meninges, we have identified a cascade of morphogenic signals initiated by the meninges that regulates corpus callosum development. The meninges prod...

The semaphorins are a large group of cell surface and secreted proteins implicated in axonal pathfinding. Here we show that the secreted mouse semaphorin D (SemD) is synthesized as an inactive precursor (proSemD) and becomes repulsive for sensory and sympathetic neurites upon proteolytic cleavage. ProSemD processing can be blocked completely by an inhibitor selective for furin-like endoprotease...

The model system, Xenopus laevis, has been used in innumerable research studies and has contributed to the understanding of multiple cytoskeletal components, including actin, microtubules, and neurofilaments, during axon pathfinding. Xenopus developmental stages have been widely characterized, and the Xenopus genome has been sequenced, allowing gene expression modifications through exogenous mo...