Beyond regulation of male sexual function, the increasing evidence shows that androgens and androgen receptor (AR) have a variety physiological pathological effects on skin. Skin cells express all metabolizing enzymes are required for independent skin synthesis development hyperandrogenic related disorders such as acne, hirsutism androgenetic alopecia. Targeting various elements function metabo...

Granulomas are focal infiltrates consisting mainly of macrophages or macrophage-derived cells (epithelioid, giant cells), chiefly in the case impossibility slow degradation specific antigens. The variability manifestations complicates clinical and pathological diagnosis granulomatous skin diseases due to individual patient reactivity specifics often unidentified triggering factors. mini-review ...

Merkel cell carcinoma (MCC) is an uncommon highly aggressive skin malignancy with an increased tendency to recur locally, invade regional lymph nodes, and metastasize distally to lung, liver, brain, bone, and skin. The sun-exposed skin of head and neck is the most frequent site of involvement (55%). We report the case of a 63-year-old Caucasian male patient who presented with a recurrent left i...

The aim of the present study was to detect the expression of the key molecules, including transforming growth factor‑β1 (TGF-β1), phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) of TGF‑β1/mammalian target of rapamycin (mTOR) pathway in pathological scar fibroblasts. Immunofluorescence, reverse transcription‑polymerase chain reaction (RT‑PCR) and western blot analysis were used to d...