Nicotine has been reported to normalize deficits in auditory sensory gating in the cases of schizophrenia, suggesting an involvement of nicotinic acetylcholine receptors in attentional abnormalities. However, the mechanism remains unclear. The present study investigated the effects of nicotine on the disruption of prepulse inhibition (PPI) of the acoustic startle response induced by apomorphine...

Abstract Background The scale-up of evidence-based innovations is required to reduce waste and inequities in health social services (HSS). However, it often tends be a top-down process initiated by policy makers, the values intended beneficiaries are forgotten. Involving multiple stakeholders including patients public scaling-up thus essential but highly complex. We propose identify relevant st...

BACKGROUND While Patient and Public Involvement (PPI) is encouraged throughout the research process, engagement is typically limited to intervention design and post-analysis stages. There are few approaches to participatory data analyses within complex health interventions. METHODS Using qualitative data from a feasibility randomised controlled trial (RCT), this proof-of-concept study tests t...

The aim of this study was to investigate the involvement of serotonin-1A (5-HT(1A)) receptors in the effects of 3,4-methylenedioxymetamphetamine (MDMA) on prepulse inhibition of acoustic startle (PPI) by comparing male and female wild-type (WT) mice and 5-HT(1A) receptor knockout (1AKO) mice. MDMA dose-dependently decreased PPI in male and female mice although female mice were more sensitive at...