Transcription comprises a highly regulated sequence of intrinsically stochastic processes, resulting in bursts of transcription intermitted by quiescence. In transcription activation or repression, a transcription factor binds dynamically to DNA, with a residence time unique to each factor. Whether the DNA residence time is important in the transcription process is unclear. Here, we designed a ...

BACKGROUND AND PURPOSE Residence in the Southeastern United States (US) has been linked to increased stroke incidence and mortality. However, data on regional variability in overall cardiovascular disease (CVD) and specific coronary heart disease incidence are sparse. METHODS We assessed the risk of major CVD (nonfatal stroke, nonfatal myocardial infarction, or death from CVD) and specific CV...

A 2D Hydrodynamic-Particle Analysis model was applied to the Gulf of Kachchh (GoK) to estimate the residence time of pollutants. The tidal currents in the Gulf have a strong E-W component, which prevents the material in the north being transported towards south. In the regions situated very close to the open boundary, where the GoK waters exchange freely with the northern Arabian Sea, dilution ...

A Mobile Ambient Laboratory (MAL) was placed at a residence in a community with two swine‐barn emission sites and one land application area to observe real‐time atmospheric stability, ammonia (NH3) and hydrogen sulfide (H2S) concentrations surrounding and within the residence during a 12‐week period. Significant differences in NH3 and H2S concentrations with atmospheric stability were found. Fo...

spatial measurements of conductivity, temperature and depth were used to study salinity variations along the principal channels of the tidal hypersaline creek network in the vicinity of bushehr port, persian gulf during three 25- tidal cycles in both warm and cold months. salinity variations and tidal fluctuations were out of phase throughout the short inverse estuary. the salinity values insid...

To determine the intercyclic effect of oxytocin and carbetocin on equine myometrial tissue, the effect of the drugs was evaluated through pharmacokinetic and pharmacodynamic studies. The complete pharmacokinetic profile for oxytocin was unknown and had to be established. To do so, 25 IU of oxytocin were administered intravenously to six cycling mares and blood samples were collected before and ...

Sialylated recombinant human acetylcholinesterase (rHuAChE), produced by stably transfected cells, is composed of a mixed population of monomers, dimers and tetramers and manifests a time-dependent circulatory enrichment of the higher-order oligomeric forms. To investigate this phenomenon further, homogeneous preparations of rHuAChE differing in their oligomerization statuses were generated: (1...