Tamarindus indica has several folkloric uses in the treatment of various ailments. This study evaluated analgesic activity methanol leaf extract (MLETI) mice and Wistar rats. Acute toxicity studies were conducted using both modified method Lorke OECD 425 guidelines. The was tested acetic acid-induced writhing test, hot plate formalin-induced hind-paw licking. Glycosides, flavonoids, saponins, a...

We evaluated the effect of buprenorphine, a mixed agonist for μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20, μg/kg, exhibited naloxone-reversible analgesic activity in naïve rats. In contrast, buprenorphine at 0.5 - 20 μg/kg produced a naloxonesensitive antihyperalgesic ...

The effects of CB1 receptor agonist HU-210 and cannabinoid CB1 receptor antagonist SR 141716A on nociception of male Wistar rats with a model of depression (bilateral olfactory bulbectomy, OBX) were studied. HU-210 (5 μg) and SR 141716A (3 μg) were acutely microinjected i.c.v. on the developed depression background. Nociception was examined as applied mechanical pressure on the left hind paw of...

The aim is to evaluation of anti-inflammatory effect of Venlafaxine in Wistar Albino Rats. Wistar Albino rats were used in the study. Total 18 rats were divided into three groups each of 6 rats. G-A (Control), G-BAspirin (300 mg/kg) and G-C (Venlafaxine (50 mg/kg). All the drugs given 30 min before induction of paw inflammation by Carrageenan. Data was expressed by MEAN±SD and percentage (%). S...

The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 ...

RATIONALE Draksharishta (DRK) is an Ayurvedic formulation approved by the "National formulary of Ayurvedic Medicine 2011", of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. But there are very scientific evidences available to support their common uses. OBJECTIVES Our present studies make an attem...

We investigated whether c-fos expression in the dorsal horn is affected by licking in the formalin test. Thirty adult Sprague-Dawley rats were divided into 5 groups of 6 rats each: a free condition control (Free Cont) group, formalin test under free condition (Free F-test) group, scrub stimulation under free condition (Free Scrub) group, restrained condition control (Restricted Cont) group, and...